User:Jessica Bun/Sandbox1: Difference between revisions

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==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==

<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene='69/698113/Rainbow-colored_spectrum/1'>TextToBeDisplayed'>

~~This~~ is a ~~default text~~ for ~~your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs~~.

The MgtC protein is a membrane-bound protein that has been found to be a critical virulence factor for intramacrophage growth.

You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

This domain of MgtC, in contrast, is highly variable in comparison to several orthologues, as presented by Yang et al. However, through a sequence alignment of five known functional MgtC orthologues from pathogens that survive inside macrophages (''M. tuberculosis, B. melitensis, B. cenocepacia, Y. pestis,'' and ''S. Typhimurium''), seven strictly conserved residues were found to be scattered along the whole sequence of the relatively hydrophilic and soluble C-terminal domain.

A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.

[[Image:Final_Final_Core_Logo.PNG |625× 116px|thumb|left|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.

[[Image:Final_Surface_Web_Logo.PNG |625× 121px|thumb|left|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

[[Image:Entire_Web_Logo.PNG |617 × 125 px|thumb|left|Seven strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

In the

Additionally, there is a crystal structure available for this domain. When comparing the crystal structure of the C-terminal domain to other protein structures, there are striking similarities between this domain and a class of proteins known as ACT domains.

===Mechanism===

~~== Disease ==~~

~~== Relevance ==~~

== Structural highlights ==

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[[Image:2lqj_colorful.png |100 px|left|thumb|Simple Structure]]

~~This is~~ a ~~sample scene created with SAT to~~ <scene name=~~"/12~~/~~3456~~/~~Sample~~/1">~~color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation~~</scene> of the protein~~. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes~~.

Among the family of MgtC proteins, there are very few residues that are conserved, especially among a highly variable C-terminal. Three conserved residues exist on the <scene name='69/698113/Conserved_surface/1'>surface</scene> of the protein.

</StructureSection>

== References ==

@@ Line 1: / Line 1: @@
 ==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==
-<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene=''>
+<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene='69/698113/Rainbow-colored_spectrum/1'>TextToBeDisplayed'>
-This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+The MgtC protein is a membrane-bound protein that has been found to be a critical virulence factor for intramacrophage growth.
 You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
+This domain of MgtC, in contrast, is highly variable in comparison to several orthologues, as presented by Yang et al. However, through a sequence alignment of five known functional MgtC orthologues from pathogens that survive inside macrophages (''M. tuberculosis, B. melitensis, B. cenocepacia, Y. pestis,'' and ''S. Typhimurium''), seven strictly conserved residues were found to be scattered along the whole sequence of the relatively hydrophilic and soluble C-terminal domain.
+A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.
+[[Image:Final_Final_Core_Logo.PNG |625× 116px|thumb|left|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]
+The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.
+[[Image:Final_Surface_Web_Logo.PNG |625× 121px|thumb|left|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]
+[[Image:Entire_Web_Logo.PNG |617 × 125 px|thumb|left|Seven strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]
+In the
+Additionally, there is a crystal structure available for this domain.  When comparing the crystal structure of the C-terminal domain to other protein structures, there are striking similarities between this domain and a class of proteins known as ACT domains.
 ===Mechanism===
-== Disease ==
-== Relevance ==
 == Structural highlights ==
@@ Line 16: / Line 33: @@
 [[Image:2lqj_colorful.png |100 px|left|thumb|Simple Structure]]
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+Among the family of MgtC proteins, there are very few residues that are conserved, especially among a highly variable C-terminal. Three conserved residues exist on the <scene name='69/698113/Conserved_surface/1'>surface</scene> of the protein.
 </StructureSection>
 == References ==
 <references/>