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<StructureSection load="1rta" size="400" color="" spin="on" Scene= caption='Ribonuclease A (magenta) complex with thymidilic acid DNA tetramer (pink), [[1rta]]' > | |||
'''Ribonuclease''' (RNase) degrades RNA. The endonucleases cleave single or double stranded RNA and include RNase III, A, T1 H and P. Exo-RNases remove terminal nucleotide from the ends of the RNA molecule. They include RNase II D, T, PH, Polynucleotide Phosphorylase (PNPase) and oligoribonuclease (ORNase).
<br /> | |||
* '''RNase A''' cleaves C or U of single-stranded RNA (ssRNA).<br /> | |||
* '''RNase BA''' is RNase from ''Bacillus amyloliquefaciens''.<br /> | |||
* '''RNase D''' degrades 3'-end pre-tRNA.<br /> | |||
* '''RNase H''' cleaves RNA/DNA double-strand to produce ssDNA.<br /> | |||
* '''RNase I''' cleaves 3'-end of ssRNA.<br /> | |||
* '''RNase II''' degrades 3'-end ssRNA.<br /> | |||
* '''RNase III''' cleaves rRNA.<br /> | |||
* '''RNase 5''' is known as angiogenin and is a potent stimulator of new blood vessels formation.<br /> | |||
* '''RNase P''' is a ribozyme.<br /> | |||
* '''RNase S''' is RNase A cleaved by subtilisin.<br /> | |||
* '''RNase SA''' is RNase from ''Streptomyces auerofaciens''.<br /> | |||
* '''RNase T''' is involved in RNA maturation.<br /> | |||
* '''RNase T1''' cleaves 3'-end G from ssRNA.<br /> | |||
* '''RNase U2''' cleaves 3'-end A from ssRNA.<br /> | |||
* '''α-sarcin''' is a cytotoxic RNase which cleaves a phosphodiester bond in a conserved rRNA loop and inactivates the ribosome.<br /> | |||
* '''oligoribonuclease''' is an exoribonuclease which cleaves 3'-end of viral RNA-DNA hybrid.<br /> | |||
* '''Polynucleotide phosphorylase''' is a bifunctional enzyme which has exoribonuclease activity.<br /> | |||
* '''Binase''' is a microbial RNase which cleaves endonucleolyticly ssRNA.<br /> | |||
* '''Poly(A)-specific RNase''' cleaves exonucleolyticly the poly(A) tail.<br /> | |||
For more details on RNase A see:<br /> | |||
<br /> | |||
*[[RNase A]] <br /> | |||
*[[Ribonuclease A Catalysis]]<br /> | |||
*[[RNase A Oligomers]]<br /> | |||
*[[RNase A NMR]]<br /> | |||
*[[User:R. Jeremy Johnson/RNaseA]]<br /> | |||
*[[RNaseA Nobel Prizes]].<br /> | |||
For RNase B and RNase S see [[RNaseS RNaseB]]. | |||
{{Clear}} | |||
==Active Site of Ribonuclease A== | |||
Ribonuclease A cleaves RNA strands by catalyzing a transphosphorylation reaction where the 2'-OH of the ribose sugar attacks the neighboring phosphate, releasing the ribose on the the other side of the phosphate. This structure shows ribonuclease A (in blue) bound to short DNA strand composed of four thymidines (in pink). Ribonuclease binds tightly to DNA, but since DNA is missing the 2'-OH, ribonuclease does not cleave it. <scene name='Goodsell_Sandbox/Ribonuclease_catalytic_site/2'>Three amino acids</scene> are shown that are important for catalysis. The 3' carbon on the DNA is shown in red--it is the site where the 2'-OH is connected in RNA. The two histidines perform the proton transfers that are needed in the reaction, and the lysine stabilizes the intermediate that is formed as the 2'-OH attacks the phosphate. Ribonuclease cleaves RNA strands best next to cytidine and uridine nucleotides--the reason for this may be seen in a <scene name='Goodsell_Sandbox/Ribonuclease_recognition/2'>spacefilling representation</scene>. Notice that the small pyrimidine base is surrounded by protein atoms. A larger purine base would not fit well in this space.<ref>PMID:1429575</ref> | |||
{{Clear}} | |||
==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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**[[3mwq]], [[3mx8]], [[3i67]], [[3i6f]], [[3i6h]], [[3i6j]], [[3i7w]], [[3eux]], [[3euy]], [[3euz]], [[3ev0]], [[3ev1]], [[3ev2]], [[3ev3]], [[3ev4]], [[3ev5]], [[3ev6]], [[3dh5]], [[2e3w]], [[2g4w]], [[2g4x]], [[2gbq]], [[2blp]], [[2blz]], [[2jvt]], [[1jvv]], [[1js0]], [[1fs3]], [[1kf2]], [[1kf3]], [[1kf4]], [[1kf5]], [[1kf7]], [[1kf8]], [[1aqp]], [[1a2w]], [[1rnw]], [[1rnz]], [[1rno]], [[1rnq]], [[1rbx]], [[1ssc]], [[3srn]], [[4srn]], [[1srn]], [[5rsa]], [[1afu]], [[1bel]], [[1c0b]], [[1c0c]], [[1lsq]], [[1rat]], [[1rbn]], [[1rha]], [[1rhb]], [[1rnx]], [[1rny]], [[1rsm]], [[1xps]], [[1xpt]], [[2g8q]], [[2rat]], [[3mzq]], [[3mzr]], [[3rat]], [[3rn3]], [[4rat]], [[5rat]], [[6rat]], [[7rat]], [[7rsa]], [[8rat]], [[8rsa]], [[9rat]], [[9rsa]], [[3mwr]], [[4ao1]] - bRNase I pancreatic - bovine<br /> | **[[3mwq]], [[3mx8]], [[3i67]], [[3i6f]], [[3i6h]], [[3i6j]], [[3i7w]], [[3eux]], [[3euy]], [[3euz]], [[3ev0]], [[3ev1]], [[3ev2]], [[3ev3]], [[3ev4]], [[3ev5]], [[3ev6]], [[3dh5]], [[2e3w]], [[2g4w]], [[2g4x]], [[2gbq]], [[2blp]], [[2blz]], [[2jvt]], [[1jvv]], [[1js0]], [[1fs3]], [[1kf2]], [[1kf3]], [[1kf4]], [[1kf5]], [[1kf7]], [[1kf8]], [[1aqp]], [[1a2w]], [[1rnw]], [[1rnz]], [[1rno]], [[1rnq]], [[1rbx]], [[1ssc]], [[3srn]], [[4srn]], [[1srn]], [[5rsa]], [[1afu]], [[1bel]], [[1c0b]], [[1c0c]], [[1lsq]], [[1rat]], [[1rbn]], [[1rha]], [[1rhb]], [[1rnx]], [[1rny]], [[1rsm]], [[1xps]], [[1xpt]], [[2g8q]], [[2rat]], [[3mzq]], [[3mzr]], [[3rat]], [[3rn3]], [[4rat]], [[5rat]], [[6rat]], [[7rat]], [[7rsa]], [[8rat]], [[8rsa]], [[9rat]], [[9rsa]], [[3mwr]], [[4ao1]] - bRNase I pancreatic - bovine<br /> | ||
**[[3a1r]] - bRNase I pancreatic - | **[[3a1r]] - bRNase I pancreatic - neutron<br /> | ||
**[[2aas]] - bRNase I pancreatic - NMR<br /> | |||
**[[3i7x]], [[3i7y]], [[3fkz]], [[3fl3]], [[3dh6]], [[3di7]], [[3di8]], [[3di9]], [[3dib]], [[3dic]], [[2oqf]], [[3bcm]], [[3bco]], [[3bcp]], [[2nui]], [[2op2]], [[1ymn]], [[1ymr]], [[1ymw]], [[2apq]], [[1izp]], [[1izq]], [[1izr]], [[1kh8]], [[1c8w]], [[1eic]], [[1eid]], [[1eie]], [[1dy5]], [[3rsd]], [[3rsk]], [[1ssa]], [[1ssb]], [[1a5p]], [[1a5q]], [[1c9v]], [[1c9x]], [[3rsp]], [[4rsd]], [[3ql1]], [[3ql2]], [[3rh1]], [[3rid]] - bRNase I pancreatic (mutant)<br /> | |||
**[[3lxo]], [[3jw1]], [[3djo]], [[3djp]], [[3djq]], [[3djv]], [[3djx]], [[3dxg]], [[3dxh]], [[2w5g]], [[2w5i]], [[2w5k]], [[2w5l]], [[2w5m]], [[3d6o]], [[3d6p]], [[3d6q]], [[3d7b]], [[3d8y]], [[3d8z]], [[2pca]], [[2g8r]], [[1z6d]], [[1z6s]], [[1u1b]], [[1w4o]], [[1w4p]], [[1w4q]], [[1wbu]], [[1o0f]], [[1jn4]], [[1jvu]], [[1f0v]], [[1ruv]], [[1rnm]], [[1rnn]], [[1rbw]], [[1rca]], [[1rpf]], [[1rpg]], [[1rph]], [[1rnc]], [[1rnd]], [[1rob]], [[1rta]], [[1rtb]], [[1afk]], [[1afl]], [[1eos]], [[1eow]], [[1o0h]], [[1o0m]], [[1o0n]], [[1o0o]], [[1qhc]], [[1rcn]] - bRNase I pancreatic + nucleotide<br /> | |||
**[[1rar]], [[1ras]] - bRNase I pancreatic fluoroscent<br /> | **[[1rar]], [[1ras]] - bRNase I pancreatic fluoroscent<br /> | ||
**[[6rsa]] - bRNase I pancreatic + nucleotide - neutron<br /> | |||
**[[3fl0]], [[3fl1]], [[4rsk]] - bRNase I pancreatic (mutant) + nucleotide <br /> | |||
**[[2xog]], [[2xoi]], [[2q4g]], [[1dfj]], [[4g8v]], [[4g8y]], [[4g90]] - bRNase I pancreatic + inhibitor<br /> | |||
**[[2p42]], [[2p43]], [[2p44]], [[2p45]], [[2p46]], [[2p47]], [[2p48]], [[2p49]], [[2p4a]], [[1bzq]], [[3qsk]] - bRNase I + antibody<br /> | |||
**[[3f8g]], [[2e0j]], [[2e0l]], [[2e0m]], [[2e0o]], [[1h8x]], [[1e21]], [[1dza]] - hRNase I pancreatic (mutant) - human<br /> | |||
**[[2k11]] - hRNase I pancreatic - NMR<br /> | |||
**[[1z7x]] - hRNase I pancreatic + inhibitor<br /> | |||
**[[33ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I - Zebrafish<br /> | |||
**[[2pqx]], [[2pqv]] - EcRNase I - ''Escherichia coli''<br /> | |||
**[[2z70]], [[2ea1]] - EcRNase I + DNA<br /> | |||
**[[3tsr]] - mRNase I + inhibitor<br /> | |||
*RNase II | |||
**[[2ix0]], [[2id0]] - EcRNase II<br /> | |||
**[[2ix1]] - EcRNase II (mutant)<br /> | |||
**[[1m58]], [[1km8]], [[1km9]] - BuRNase II - Bullfrog<br /> | |||
**[[1bc4]] - BuRNase II - NMR<br /> | |||
**[[1m07]] - BuRNase II + DNA<br /> | |||
**[[2bex]] - hRNase II + RNase inhibitor protein<br /> | |||
**[[2bzz]], [[2c01]], [[2c02]], [[2c05]] - hRNase II + inhibitor<br /> | |||
*RNase III | |||
**[[2nue]], [[2nuf]], [[2nug]], [[1yyk]], [[1yyw]], [[4m2z]], [[4m30]] - AaRNase III + RNA - ''Aquifex aeolicus''<br /> | |||
**2ez6]], [[1yyo]], [[1yz9]], [[1rc7]] - AaRNase III (mutant) + RNA<br /> | |||
**[[1rc5]], [[1i4s]], [[1jfz]] - AaRNase III N terminal<br /> | |||
**[[1z5f]] - BuRNase III<br /> | |||
**[[2a11]] - MtRNase III - ''Mycobacterium tuberculosis''<br /> | |||
**[[1o0w]] - TmRNase III - ''Thermotoga maritima''<br /> | |||
**[[1t4n]], [[1t4o]] - yRNase III - yeast - NMR<br /> | |||
**[[2lbs]] - yRNase III RNA-binding domain + RNA - NMR<br /> | |||
**[[2lup]], [[4oog]] - yRNase III RNA-binding domain + RNA <br /> | |||
**[[2luq]] - yRNase III RNA-binding domain <br /> | |||
**[[2kb5]] - hRNase III - NMR<br /> | |||
**[[1dyt]], [[1qmt]], [[2khx]] - hRNase III <br /> | |||
**[[1h1h]] - hRNase III + nucleotide<br /> | |||
**[[3n3w]], [[3o2r]] - RNase III nuclease domain - ''Campylobacter jejuni''<br /> | |||
*RNase 4 | |||
**[[1wdy]] - hRNase 4 <br /> | |||
**[[2rnf]], [[1rnf]] - hRNase 4 + nucleotide<br /> | |||
**[[1kvz]] - BuRNase 4 - NMR<br /> | |||
*RNase 5 | |||
**[[1un3]], [[1un4]], [[1un5]], [[1gv7]] - hRNase 5 (mutant)<br /> | |||
**[[1h0d]] - hRNase 5 + antibody<br /> | |||
**[[3lje]] - ZeRNase 5<br /> | |||
*RNase 6 | |||
**[[1oj1]], [[1oj8]] - BuRNase 6 + nucleotide<br /> | |||
*RNase 7 | |||
**[[2hky]] - hRNase 7 - NMR <br /> | |||
*RNase A | |||
**[[1rra]] - RNase A - rat<br /> | |||
**[[44j5z]], [[4j60]], [[4j61]], [[4j62]], [[4j63]], [[4j64]], [[4j65]], [[4j66]], [[4j67]], [[4j68]], [[4j69]], [[4j6a]], [[4mxf]] - bRNase A <br /> | |||
**[[4k7m]] - bRNase A (mutant)<br /> | |||
**[[2aas]] - bRNase A - NMR<br /> | |||
**[[4kxh]] - hRNase A <br /> | |||
**[[2e33]] - bRNase A + F-box only protein 2<br /> | |||
**[[4l55]] - bRNase A + aziru<br /> | |||
*RNase B | |||
**[[1rbb]] - bRNase B <br /> | |||
**[[1rbj]] - bRNase B + tetranucleotide <br /> | |||
*RNase BA | |||
**[[1x1u]], [[1x1x]], [[1x1y]], [[1b27]], [[1b2u]], [[1b3s]], [[1x1w]] - BaRNase BA + barstar (mutant) - ''Bacillus amyloliquefaciens''<br /> | |||
**[[3da7]], [[1brs]], [[1bgs]] - BaRNase BA + barstar <br /> | |||
**[[1b2s]], [[2za4]] - BaRNase BA (mutant) + barstar (mutant) <br /> | |||
**[[1brn]], [[2kf5]], [[2kf6]], [[1rnb]] - BaRNase BA + nucleotide<br /> | |||
**[[3kch]], [[2f4y]], [[2f56]], [[2f5m]], [[2f5w]] - BaRNase BA crosslinked<br /> | |||
**[[2kf3]], [[2kf4]], [[1fw7]], [[1bnr]] - BaRNase BA - NMR<br /> | |||
**[[1yvs]], [[1b2x]], [[1a2p]], [[1bni]], [[1bnj]] - BaRNase BA <br /> | |||
**[[1b20]], [[1b21]], [[1b2z]], [[1bne]], [[1bnf]], [[1bng]], [[1brh]], [[1bri]], [[1brj]], [[1brk]], [[1bns]], [[1brg]], [[1bsa]], [[1bsb]], [[1bsc]], [[1bsd]], [[1bse]], [[1bna]], [[1bao]] - BaRNase BA (mutant)<br /> | |||
*RAase D | |||
**[[1yt3]] - EcRNase D<br /> | |||
*RNase E | |||
**[[2vmk]], [[2c4r]], [[2bx2]] - EcRNase E catalytic domain<br /> | |||
**[[1slj]] - EcRNase E S1 domain - NMR<br /> | |||
**[[1smx]], [[1sn8]] - EcRNase E S1 domain <br /> | |||
**[[2vrt]], [[2c0b]] - EcRNase E catalytic domain + RNA<br /> | |||
**[[3h8a]] - EcRNase E recognition domain + enolase<br /> | |||
*RNase F1 | |||
**[[1fus]], [[1fut]] - GfRNase F1 + nucleotide - ''Gibberella fujikuroi''<br /> | |||
**[[1rck]], [[1rci]] - GfRNase F1 - NMR<br /> | |||
*RNase H | |||
**[[3h7i]], [[3h8s]], [[3h8w]] - T4RNase H (mutant) - Enterobacteria phage T4<br /> | |||
**[[2ihn]] - T4RNase H (mutant) + DNA<br /> | |||
**[[3h8j]], [[1tfr]] - T4RNase H <br /> | |||
**[[4e89]] - RNase H - XMRV<br /> | |||
**[[2rpi]], [[1ril]] - TtRNase H - ''Thermus thermophilus''<br /> | |||
**[[1rbr]], [[1rbs]], [[1rbt]], [[1rbu]], [[1rbv]], [[2rn2]] - EcRNase H <br /> | |||
**[[1lav]], [[1law]], [[1rda]], [[1rdb]], [[1rdc]] - EcRNase H (mutant) <br /> | |||
**[[1jl2]] - EcRNase H/TtRNase H <br /> | |||
**[[3d0p]], [[3ey1]], [[3i8d]] - BhRNase H (mutant) + DNA - ''Bacillus halodurans''<br /> | |||
**[[1zbf]] - BhRNase H (mutant) <br /> | |||
**[[2r7y]], [[2g8f]], [[2g8h]], [[2g8i]], [[2g8k]], [[2g8u]], [[2g8v]], [[2g8w]], [[1zbi]], [[1zbl]], [[3twh]], [[3uld]] - BhRNase H (mutant) + RNA + DNA<br /> | |||
**[[4htu]], [[4hue]], [[4huf]], [[4hug]] - BhRNase H + DNA<br /> | |||
**[[4ibn]] - uRNase H - uncultured<br /> | |||
**[[4h8k]] - uRNase H + RNA + DNA<br /> | |||
*RNase HI | |||
**[[2qk9]], [[2qkb]], [[2qkk]] - hRNase HI (mutant) + RNA + DNA<br /> | |||
**[[3h08]] - RNase HI - ''Chlorobaculum tepidum''<br /> | |||
**[[3aa2]], [[3aa3]], [[3aa4]], [[3aa5]], [[2yv0]], [[2z1g]], [[2z1h]], [[2z1i]], [[2z1j]], [[1wse]], [[1wsf]], [[1wsg]], [[1wsh]], [[1wsi]], [[1wsj]], [[1jxb]], [[1jl1]], [[1f21]], [[1kva]], [[1kvb]], [[1kvc]], [[1goa]], [[1gob]], [[1goc]] - EcRNase HI (mutant) <br /> | |||
**[[1g15]], [[1rdd]], [[1rnh]] - EcRNase HI <br /> | |||
**[[1rch]] - EcRNase HI - NMR <br /> | |||
**[[2zqb]] - SoRNase HI (mutant) - ''Shewanella oneidensis''<br /> | |||
**[[2e4l]] - SoRNase HI <br /> | |||
**[[3bsu]] - hRNase HI catalytic domain + RNA + DNA<br /> | |||
**[[2ehg]] - RNase HI - ''Sulfolobus tokodaii''<br /> | |||
**[[1qhk]] - yRNase HI N terminal - NMR<br /> | |||
**[[3u3g]] - uRNase HI<br /> | |||
**[[4e19]], [[4nyn]] - RNase HI - ''Halobacterium salinarium''<br /> | |||
*RNase HII | |||
**[[3p83]] - AfRNase HII + DNA polymerase sliding clamp - ''Archaeoglobus fulgidus''<br /> | |||
**[[1i39]], [[1i3a]] - AfRNase HII <br /> | |||
**[[3puf]], [[3p56]], [[3p5j]] - hRNase HII subunits α+β+γ<br /> | |||
**[[3kio]] - mRNase HII subunits α+β+γ - mouse<br /> | |||
**[[3o3g]] - TmRNase HII + DNA<br /> | |||
**[[3o3f]], [[3o3h]], [[4hht]] - TmRNase HII (mutant) + DNA<br /> | |||
**[[2etj]] - TmRNase HII <br /> | |||
**[[1x1p]], [[1io2]] - TkRNase HII - ''Thermococcus kodakarensis''<br /> | |||
**[[2dfe]], [[2dff]], [[2dfh]] - TkRNase HII (mutant) <br /> | |||
**[[1eke]] - RNase HII - ''Methanocaldococcus jannaschii''<br /> | |||
*RNase HIII | |||
**[[2d0a]], [[2d0b]], [[2d0c]] - GsRNase HIII - ''Geobacillus stearothermophilus''<br /> | |||
**[[3asm]] - GsRNase HIII (mutant) <br /> | |||
**[[1uax]] - PhRNase HIII - ''Pyrococcus horikoshii'' <br /> | |||
**[[3vn5]] - AaRNase HIII <br /> | |||
*RNase J | |||
**[[3bk1]] - TtRNase J <br /> | |||
**[[3bk2]] - TtRNase J + nucleotide<br /> | |||
**[[3zq4]] - BsRNase J1 - ''Bacillus subtilis'' <br /> | |||
*RNase L | |||
**[[4o1o]] - pRNase L + oligoadenylate + CMP - pig <br /> | |||
**[[4o1p]] - pRNase L + oligoadenylate + AMPPNP <br /> | |||
**[[4oav]] - pRNase L + oligoadenylate + AMPPCP + RNA<br /> | |||
*RNase LE | |||
**[[1dix]] - RNase LE - ''Solanum lycopersicum''<br /> | |||
*RNase MAR1 | |||
**[[1xn4]] - RNase MAR1 - ''Leishmania major''<br /> | |||
**[[2b34]] - RNase MAR1 - ''Caenorhabditis elegans''<br /> | |||
*RNase MS | |||
**[[1rms]], [[1rds]] - RNase MS - ''Aspergillus phoenicis''<br /> | |||
*RNase MC1 | |||
**[[1v9h]], [[1j1f]], [[1j1g]] - McRNase MC1 (mutant) + nucleotide - ''Momordica charantia''<br /> | |||
**[[1ucg]] - McRNase MC1 (mutant) <br /> | |||
**[[1uca]], [[1ucc]], [[1ucd]] - McRNase MC1 + nucleotide <br /> | |||
**[[1bk7]] - McRNase MC1 <br /> | |||
*RNase NT | |||
**[[1vcz]], [[1vd1]], [[1vd3]] - NgRNase NT + nucleotide - ''Nicotiana glutinosa''<br /> | |||
**[[1iyb]] - NgRNase NW <br /> | |||
*RNase P | |||
**[[3ok7]], [[3okb]], [[3q1q]], [[3q1r]] - TmRNase P + TmRNase P RNA + tRNAPhe <br /> | |||
**[[1nz0]] - TmRNase P <br /> | |||
**[[1d6t]] - RNase P - ''Staphylococcus aureus''<br /> | |||
**[[2a64]] - GsRNase P (mutant) <br /> | |||
**[[1a6f]], [[1nbs]], [[2jg4]] - BsRNase P (mutant) <br /> | |||
**[[1ts9]], [[1tsf]] - AfRNase P <br /> | |||
**[[1u9s]] - RNase P - synthetic <br /> | |||
**[[2avs]] - PfRNase P (mutant) - ''Pyrococcus furiosus'' <br /> | |||
**[[2k3r]]. [[2ki7]] - PfRNase P <br /> | |||
**[[2ljp]] - EcRNase P <br /> | |||
**[[2av5]] - PhRNase P component 2<br /> | |||
**[[1x0t]] - PhRNase P component 4<br /> | |||
**[[2zae]] - PhRNase P components 1+4<br /> | |||
**[[2czv]] - PhRNase P component 2 (mutant) +3<br /> | |||
**[[3iab]] - yRNase P subunits POP6+POP7 + RNase MRP P3 domain<br /> | |||
*RNase PH | |||
**[[3dd6]] - RNase PH - ''Bacillus anthracis'' <br /> | |||
**[[1oyp]], [[1oyr]], [[1oys]] - BsRNase PH <br /> | |||
**[[1r6l]], [[1r6m]] - PaRNase PH - ''Pseudomonas aeruginosa''<br /> | |||
**[[3b4t]] - MtRNase PH <br /> | |||
**[[1udn]] - AaRNase PH <br /> | |||
**[[1udo]], [[1udq]], [[1uds]] - AaRNase PH (mutant)<br /> | |||
*RNase RH | |||
**[[1bol]] - RNase RH - ''Rhizopus niveus'' <br /> | |||
*RNase S | |||
**[[3oqy]], [[3oqz]], [[3or0]], [[1z3l]], [[1z3m]], [[1z3p]], [[1y92]], [[1y94]], [[1fev]], [[1d5d]], [[1d5e]], [[1d5h]], [[2rln]], [[1qwq]], [[4n4c]] - bRNase S seminal (mutant) <br /> | |||
**[[1tq9]], [[1r5c]], [[11ba]], [[11bg]] - bRNase S + nucleotide <br /> | |||
**[[1r5d]], [[1r3m]], [[1n1x]], [[1n3z]], [[1j7z]], [[1j80]], [[1j81]], [[1j82]], [[1cjq]], [[1cjr]], [[1bsr]], [[1rbc]], [[1rbd]], [[1rbe]], [[1rbf]], [[1rbg]], [[1rbh]] [[1rbi]], [[1rnu]], [[1rnv]], [[2rns]] - bRNase S <br /> | |||
**[[1b6v]] - bRNase S/bRNase A <br /> | |||
*RNase S3 | |||
**[[1iqq]] - RNase S3 - Japanese pear <br /> | |||
*RNase SA | |||
**[[3a5e]], [[1zgx]], [[1ynv]], [[1t2h]], [[1t2i]], [[1uci]], [[1ucj]], [[1uck]], [[1ucl]], [[1i70]], [[1i8v]], [[1box]], [[4gho]] - SaRNase SA guanyl-specific (mutant) - ''Streptomyces aureofaciens'' <br /> | |||
**[[1lni]], [[1c54]], [[1rge]], [[1rgf]], [[1rgg]], [[1rgh]], [[1sar]] - SaRNase SA <br /> | |||
**[[1gmp]], [[1gmq]], [[1gmr]], [[2sar]] - SaRNase SA + nucleotide <br /> | |||
**[[1ay7]] - SaRNase SA + barstar <br /> | |||
**[[1rsn]] - SaRNase SA + cyclophosphothiolate <br /> | |||
**[[1py3]], [[1pyl]] - SaRNase SA2 <br /> | |||
**[[3dgy]], [[3dh2]], [[3d4a]], [[3d5g]], [[3d5i]] - SaRNase SA2 + nucleotide <br /> | |||
**[[1mgr]], [[1mgw]] - SaRNase SA3 <br /> | |||
*RNase SF11 | |||
**[[1ioo]] - RNase SF11 - ''Nicotiana alata'' <br /> | |||
*RNase T | |||
**[[2is3]] - EcRNase T <br /> | |||
**[[3ngy]] - EcRNase T (mutant)<br /> | |||
**[[3ngz]] - EcRNase T (mutant) + nucleotide<br /> | |||
**[[3ngo]], [[3nh1]], [[3nh2]] - EcRNase T + nucleotide<br /> | |||
**[[3v9s]], [[3v9w]], [[3v9u]], [[3v9x]], [[3v9z]], [[3va0]], [[3va3]], [[4kaz]], [[4kb0]], [[4kb1]] - EcRNase T + DNA<br /> | |||
**[[2f96]] - PaRNase T <br /> | |||
*RNase T1 | |||
**[[1tto]], [[1rn1]], [[1rn4]], [[1rnt]], [[2aad]], [[2aae]] - AoRNase T1 - ''Aspergillus oryzae'' <br /> | |||
**[[1q9e]], [[1iyy]], [[1i2e]], [[1i2f]], [[1i2g]], [[1i3f]], [[1i3i]], [[1hz1]], [[1fys]], [[1fzu]], [[1ch0]], [[4bir]], [[3bir]], [[5bir]], [[1g02]], [[1hyf]], [[1trp]], [[1trq]], [[2bir]], [[4rnt]], [[5rnt]], [[6rnt]], [[7rnt]], [[8rnt]], [[9rnt]] - AoRNase T1 (mutant)<br /> | |||
**[[1lov]], [[1low]], [[1loy]], [[1i0v]], [[1i0x]], [[1b2m]], [[1rhl]], [[1bir]], [[1rgk]], [[1rgl]] - AoRNase T1 (mutant) + nucleotide<br /> | |||
**[[1bvi]], [[2bu4]], [[2hoh]], [[3hoh]], [[4hoh]], [[5hoh]], [[1gsp]], [[2gsp]]. [[3gsp]], [[4gsp]], [[5gsp]]. [[6gsp]], [[7gsp]], [[1det]], [[1rls]], [[1lra]], [[1rga]], [[1bu4]], [[1rgc]], [[3bu4]], [[4bu4]], [[5bu4]], [[3syu]], [[3urp]] - AoRNase T1 + nucleotide<br /> | |||
**[[3rnt]] - AoRNase T1 + V<br /> | |||
**[[1ygw]] - AoRNase T1 - NMR<br /> | |||
*RNase T2 | |||
**[[3t0o]] - hRNase T2<br /> | |||
*RNase U2 | |||
**[[3agn]], [[3ago]], [[3ahw]] - UsRNase U2 + AMP - ''Ustilago sphaerogena''<br /> | |||
**[[1rtu]] - UsRNase U2<br /> | |||
**[[3ahs]] - UsRNase U2B<br /> | |||
*RNase Z | |||
**[[2e7y]] - TmRNase Z<br /> | |||
**[[2fk6]], [[4gcw]] - BsRNase Z (mutant) + tRNA Thr<br /> | |||
**[[1y44]] - BsRNase Z (mutant) <br /> | |||
**[[2cbn]] - EcRNase Z<br /> | |||
**[[3v32]], [[3v33]], [[3v34]] - hRNase Z<br /> | |||
*RNase α-sarcin | |||
**[[1de3]] - AgRNase αs - ''Aspergillus giganteus''<br /> | |||
**[[1r4y]] - AgRNase αs (mutant)<br /> | |||
*Oligoribonuclease | |||
**[[2igi]], [[1yta]] - EcORNase<br /> | |||
**[[2gbz]] - ORNase - ''Xanthomonas campestris''<br /> | |||
**[[1j9a]] - ORNase - ''Haemophilus influenza''<br /> | |||
**[[3tr8]] - ORNase - ''Coxiella burnetii''<br /> | |||
*Polynucleotide phosphorylase | |||
**[[3cdi]] - EcPNPase<br /> | |||
**[[3gll]] - EcPNPase core<br /> | |||
**[[3cdj]] - EcPNPase C terminal truncated<br /> | |||
**[[1e3h]], [[1e3p]] - PNPase - ''Streptomyces antibioticus''<br /> | |||
**[[3gcm]], [[3gme]], [[3h1c]] - EcPNPase + RNase E recognition domain<br /> | |||
**[[3h36]] - PNPase fragment - ''Streptomyces mutans''<br /> | |||
*Binase | |||
**[[ | **[[1gou]], [[1gov]], [[1goy]] - BiBinase - ''Bacillus intermedius''<br /> | ||
**[[2rbi]], [[4haa]] - BiBinase (mutant)<br /> | |||
**[[1buj]] - BiBinase - NMR<br /> | |||
*Poly(A)-specific RNase | |||
**[[1ug8]] - mParn R3H domain - NMR<br /> | |||
**[[1whv]] - mParn RNA-binding domain - NMR<br /> | |||
**[[2rok]] - mParn CAP-binding domain - NMR<br /> | |||
**[[3d45]] - mParn + nucleotide<br /> | |||
**[[2a1s]] - hParn <br /> | |||
**[[2a1r]], [[3ctr]] - hParn + nucleotide<br /> | |||
*RNase pop2 | |||
**[[4b8a]] - yRNase pop2 + cell division cycle protein 39<br /> | |||
**[[4b8c]] - yRNase pop2 + cell division cycle protein 39 + CCR4<br /> | |||
*Other RNases | |||
**[[2zpo]] - RNase - ''Chelonia mydas''<br /> | |||
**[[3a4y]], [[3idz]], [[3ie0]], [[3ie2]] - TtRNase (mutant) - ''Thermus thermophilus''<br /> | |||
**[[3iek]] - TtRNase<br /> | |||
**[[3ie1]], [[3iem]] - TtRNase (mutant)<br /> | |||
**[[3iel]] - TtRNase + nucleotide<br /> | |||
}} | }} | ||