Molecular Playground/Bacterial Chemotaxis Complex: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<applet load='3UR1' size='400' color='white' frame='true' align='right' caption='A single asymmetric unit ternary complex with the truncated receptor, CheA, and CheW ([[3ur1]])' scene='57/571407/Single_ternary_complex/1'/> | <applet load='3UR1' size='400' color='white' frame='true' align='right' caption='A single asymmetric unit ternary complex with the truncated receptor (grey), CheA (blue), and CheW (cyan) ([[3ur1]])' scene='57/571407/Single_ternary_complex/1'/> | ||
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst. | One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst. | ||
| Line 7: | Line 7: | ||
===Structure=== | ===Structure=== | ||
• The <scene name='57/571407/Cytoplasmic_receptor/1'>chemoreceptor</scene> (1QU7) – also called methyl-accepting protein, MCP – is a ~380Å long, alpha helical homo-dimer with many domains. The <scene name='57/571407/Cytoplasmic_receptor/2'>signaling domain</scene> at the cytosplasmic tip is where both CheW and CheA interact and bind. | • The <scene name='57/571407/Cytoplasmic_receptor/1'>chemoreceptor</scene> (1QU7) – also called methyl-accepting protein, MCP – is a ~380Å long, alpha helical homo-dimer with many domains. The <scene name='57/571407/Cytoplasmic_receptor/3'>methylation sites</scene> (Glu295, Glu302,Glu309, Glu491) are shown by yellow color. When <scene name='57/571407/Cheb/1'>CheB</scene> interacts with the receptor, it acts as a methylestrase by removing methyl groups from these 4 residues. On the other hand <scene name='57/571407/Cher/2'>CheR</scene> acts as methyltranferase by adding methyl groups to these residues.The <scene name='57/571407/Cytoplasmic_receptor/2'>signaling domain</scene> at the cytosplasmic tip is where both CheW and CheA interact and bind. | ||
• <scene name='57/571407/Chea_p3p4p5/1'>CheA</scene> is a large 5-subdomain (P1-P5) histidine kinase that auto-phosphorylates depending on it's interaction with the receptor and localized concentrations of the response regulator protein CheY. This scene is of P3-P5 as a homo-dimer (1B3Q). For more information, see [http://proteopedia.org/wiki/index.php/Molecular_Playground/CheA CheA Molecular Playground page] | • <scene name='57/571407/Chea_p3p4p5/1'>CheA</scene> is a large 5-subdomain (P1-P5) histidine kinase that auto-phosphorylates depending on it's interaction with the receptor and localized concentrations of the response regulator protein CheY. This scene is of P3-P5 as a homo-dimer (1B3Q). For more information, see [http://proteopedia.org/wiki/index.php/Molecular_Playground/CheA CheA Molecular Playground page] | ||