Group:MUZIC:Tritopodin: Difference between revisions

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~~<Structure load~~=~~'Trit_pdz_pred.pdb' size~~=~~'400' frame~~=~~'true' align~~=~~'right' caption~~=~~'Prediction of the PDZ binding domain of Tritopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002)' scene~~=~~'Insert optional scene name here' />~~

===Synaptopodin 2-like protein / Tritopodin===

==Introduction==

~~Tritopodin~~ is the third member (besides myopodin and synaptopodin) of the podin protein family and is encoded by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.

The synaptopodin 2-like protein or '''tritopodin''' is the third member (besides [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Myopodin myopodin] and [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Synaptopodin synaptopodin]) of the podin protein family and is encoded by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.

==Sequence Annotation==

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==Tritopodin Interactions==

Tritopodin localize in the sarcomeric Z-disc, where interact with α-actinin, which was ~~verifies~~ by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. ~~Adults~~ skeletal and cardiac muscle tissue ~~shows~~ the colocalization ~~from mCHAP~~ with α-actinin in the sarcomeric Z-disc and in the nucleus in ~~embrional Cardiomyocytes~~ <ref> PMID:20215401 </ref>.

Tritopodin localize in the sarcomeric Z-disc, where interact with α-actinin, which was verified by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. In adult skeletal and cardiac muscle tissue from mCHAP was demonstrated the colocalization with α-actinin in the sarcomeric Z-disc and in the nucleus in embryonal cardiomyocytes <ref> PMID:20215401 </ref>.

==Pathology==

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-<Structure load='Trit_pdz_pred.pdb' size='400' frame='true' align='right' caption='Prediction of the PDZ binding domain of Tritopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002)' scene='Insert optional scene name here' />
+===Synaptopodin 2-like protein / Tritopodin===
 ==Introduction==
-Tritopodin is the third member (besides myopodin and synaptopodin) of the podin protein family and is encoded by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member  of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.
+The synaptopodin 2-like protein or '''tritopodin''' is the third member (besides [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Myopodin myopodin] and [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Synaptopodin synaptopodin]) of the podin protein family and is encoded by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member  of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.
 ==Sequence Annotation==
@@ Line 15: / Line 15: @@
 ==Tritopodin Interactions==
-Tritopodin localize in the sarcomeric Z-disc, where interact with α-actinin, which was verifies by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adults skeletal and cardiac muscle tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes <ref> PMID:20215401 </ref>.
+Tritopodin localize in the sarcomeric Z-disc, where interact with α-actinin, which was verified by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. In adult skeletal and cardiac muscle tissue from mCHAP was demonstrated the colocalization with α-actinin in the sarcomeric Z-disc and in the nucleus in embryonal cardiomyocytes <ref> PMID:20215401 </ref>.
 ==Pathology==