Sandbox Reserved 558: Difference between revisions

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{{NCSU_BIOL414_Sandbox}}
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Hi everyone,
Hi Blair,
Here is your very own Proteopedia Page to play with.
Here is your very own Proteopedia Page for pdb code: 3EP2.
This page is not publicly available yet,
Your presentation is scheduled for: June 11.
so don't worry about making mistakes that
other people will see.  


Have Fun!
Have Fun!


Greg Buhrman
Greg Buhrman
[[Image:3ep2.png|left|200px]]
<!--
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{{STRUCTURE_3ep2|  PDB=3ep2  |  SCENE=  }}
===Model of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EM===
<!--
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{{ABSTRACT_PUBMED_19020518}}
==About this Structure==
[[3ep2]] is a 9 chain structure of [[Ribosomal protein S12]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EP2 OCA].
==See Also==
*[[Ribosomal protein S12]]
==Reference==
<ref group="xtra">PMID:19020518</ref><references group="xtra"/>
[[Category: Escherichia coli k12]]
[[Category: Agirrezabala, X.]]
[[Category: Frank, J.]]
[[Category: Li, W.]]
[[Category: A/t-trna]]
[[Category: Acetylation]]
[[Category: Antibiotic resistance]]
[[Category: Automated data collection]]
[[Category: Cytoplasm]]
[[Category: Elongation factor]]
[[Category: Gtp-binding]]
[[Category: Membrane]]
[[Category: Methylation]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Protein biosynthesis]]
[[Category: Protein translation]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
[[Category: Ribosomal protein/rna complex]]
[[Category: Rna-binding]]
[[Category: Rrna-binding]]
[[Category: Ternary complex]]
[[Category: Trna-binding]]

Latest revision as of 20:41, 24 May 2012

This Sandbox is Reserved from 05/22/2012, through 07/22/2012 for use in the course "BIOL 414" taught by Greg Buhrman at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 551 through Sandbox Reserved 590.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
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More help: Help:Editing

Hi Blair, Here is your very own Proteopedia Page for pdb code: 3EP2. Your presentation is scheduled for: June 11.

Have Fun!

Greg Buhrman


PDB ID 3ep2

Drag the structure with the mouse to rotate
3ep2, resolution 9.00Å ()
Related: 2avy, 2aw4, 1qza, 1ob2, 3eq3, 3eq4
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Model of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EMModel of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EM

Publication Abstract from PubMed

The accuracy of ribosomal translation is achieved by an initial selection and a proofreading step, mediated by EF-Tu, which forms a ternary complex with aminoacyl(aa)-tRNA. To study the binding modes of different aa-tRNAs, we compared cryo-EM maps of the kirromycin-stalled ribosome bound with ternary complexes containing Phe-tRNA(Phe), Trp-tRNA(Trp), or Leu-tRNA(LeuI). The three maps suggest a common binding manner of cognate aa-tRNAs in their specific binding with both the ribosome and EF-Tu. All three aa-tRNAs have the same 'loaded spring' conformation with a kink and twist between the D-stem and anticodon stem. The three complexes are similarly integrated in an interaction network, extending from the anticodon loop through h44 and protein S12 to the EF-Tu-binding CCA end of aa-tRNA, proposed to signal cognate codon-anticodon interaction to the GTPase centre and tune the accuracy of aa-tRNA selection.

Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM., Li W, Agirrezabala X, Lei J, Bouakaz L, Brunelle JL, Ortiz-Meoz RF, Green R, Sanyal S, Ehrenberg M, Frank J, EMBO J. 2008 Dec 17;27(24):3322-31. Epub 2008 Nov 20. PMID:19020518

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this StructureAbout this Structure

3ep2 is a 9 chain structure of Ribosomal protein S12 with sequence from Escherichia coli k12. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Li W, Agirrezabala X, Lei J, Bouakaz L, Brunelle JL, Ortiz-Meoz RF, Green R, Sanyal S, Ehrenberg M, Frank J. Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J. 2008 Dec 17;27(24):3322-31. Epub 2008 Nov 20. PMID:19020518 doi:10.1038/emboj.2008.243

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Greg Buhrman
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