Sandbox Reserved 498: Difference between revisions
No edit summary |
|||
| Line 12: | Line 12: | ||
[[Image:ubc9.gif|250px|left]] | [[Image:ubc9.gif|250px|left]] | ||
==Background== | ==Background== | ||
Ubc9, PDB file: [[ | Ubc9, PDB file: [[1u9a]] an ubiquitin conjugating enzyme, participates not in the ubiquitinylation pathway but in the sumoylation pathway. This pathway links a SUMO molecule to a targeted protein.<ref name="Filip">PMID:14739995</ref> | ||
Ubc9’s conjugation with [[SUMO]] and not [[ubiquitin]] results in the targeted protein being tagged not for degradation, but to modify the protein for use in regulation, enhancing protein activity, and/or cell cycle functions.<ref name="Muller">PMID:11265250</ref><ref name="Victor">PMID:11853669</ref> | Ubc9’s conjugation with [[SUMO]] and not [[ubiquitin]] results in the targeted protein being tagged not for degradation, but to modify the protein for use in regulation, enhancing protein activity, and/or cell cycle functions.<ref name="Muller">PMID:11265250</ref><ref name="Victor">PMID:11853669</ref> | ||
Ubc9 is one of the 35 known mammalian ubiquitin-conjugating enzymes. These Ubcs bind to ubiquitin or ubiquitin –like proteins.<ref name="Sjored">PMID:19940261</ref> | Ubc9 is one of the 35 known mammalian ubiquitin-conjugating enzymes. These Ubcs bind to ubiquitin or ubiquitin –like proteins.<ref name="Sjored">PMID:19940261</ref> | ||
==Structure== | ==Structure== | ||