Molecular Playground/ADAM13: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Genevieve Abbruzzese, Michal Harel

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-One of the [[CBI Molecules]] being studied in the  [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
+'''ADAM13''' is one of the [[CBI Molecules]] being studied in the  [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
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 <applet size='[450,338]' frame='true' align='right'
 scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
-caption='ADAM13 homology model against ADAM22[[3g5c]]' />
+caption='ADAM13 homology model against ADAM22  [[3g5c]]' />
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-Most ADAMs contain a canonical metalloprotease site (HExxHxxGxxH) with a catalytic glutamate residue (shown in red) three Histidine residues (blue) coordinating a Zinc ion (green). ADAMs are known to cleave a variety of proteins present at the cell surface in addition to cell adhesion molecules, such as signaling receptors and their ligands to either activate or inactivate the signaling pathway. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.
+Most ADAMs contain the canonical metalloprotease active site sequence (HExxHxxGxxH) with a catalytic glutamate residue (shown below in red) three Histidine residues (blue) that coordinate a zinc ion (green). In addition to cell adhesion molecules, ADAMs are known to cleave a variety of other biologically important proteins present at the cell surface, such as signaling receptors and their ligands to either activate or inactivate multiple signaling pathways. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.
 [[Image:ADAM33metallo.png]]
+{{Template:Molecular Playground animation description}}
+[[Category: Molecular Playground]]