Sandbox 27: Difference between revisions
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However we can remark that the M22–TSHR complex involves more strong interactions and fewer hydrophobic interactions than the TSH–TSHR complex. That can explain the effects of the binding of autoantibody like M22. So the idendification of interaction residues and understanding of the mechanism may be useful for developing means of inhibiting TSHR autoantibodies binding. | However we can remark that the M22–TSHR complex involves more strong interactions and fewer hydrophobic interactions than the TSH–TSHR complex. That can explain the effects of the binding of autoantibody like M22. So the idendification of interaction residues and understanding of the mechanism may be useful for developing means of inhibiting TSHR autoantibodies binding. | ||
Other 3D structure of complexes between TSHR and autoantibodies from pdb: [http://www.rcsb.org/pdb/explore/explore.do?structureId=2XWT 2xwt] | |||
== Diseases == | == Diseases == | ||