Sandbox Reserved 168: Difference between revisions
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== SKI protein == | == SKI protein == | ||
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== Background == | == Background == | ||
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== Function == | == Function == | ||
SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling from telling the cell to slow down and stop dividing. It is also involved in the regulation of cellular transformation and differentiation. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovered that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. Scientists have previously shown that Ski disrupts normal cell functioning by directly disrupting the expression of genes inside the cell’s nucleus<ref name="function"> Walsh K, Rowe M.Fall 2002. Scientists Identify the role of Important Cancer Protein. Brookhaven National Laboratory. http://www.bnl.gov/bnlweb/pubaf/pr/2002/bnlpr103102.htm </ref> | SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling from telling the cell to slow down and stop dividing. It is also involved in the regulation of cellular transformation and differentiation<ref name="function"> Medrano E. 2003. Repression of TGF-B signaling by the oncogenic protein SKI in human melanomas: Consequences for proliferation, survival, and metastasis. http://www.nature.com/onc/journal/v22/n20/full/1206452a.html</ref>. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovered that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. Scientists have previously shown that Ski disrupts normal cell functioning by directly disrupting the expression of genes inside the cell’s nucleus<ref name="function"> Walsh K, Rowe M.Fall 2002. Scientists Identify the role of Important Cancer Protein. Brookhaven National Laboratory. http://www.bnl.gov/bnlweb/pubaf/pr/2002/bnlpr103102.htm </ref> | ||
== Clinical Applications == | == Clinical Applications == | ||
SKI has been linked to various types of cancer such as melanoma, esophageal cell carcinoma, cervical cancer and the process of tumor progresssion. The SKI oncoprotein has been demonstrated to assist tyrosine kinases to cause leukemia, recently it has been demonstrated that the protein also plays a regulatory role in several signal transduction pathways that are frequent targets for mutagenesis in human tumors. | SKI has been linked to various types of cancer such as melanoma, esophageal cell carcinoma, cervical cancer and the process of tumor progresssion. The SKI oncoprotein has been demonstrated to assist tyrosine kinases to cause leukemia, recently it has been demonstrated that the protein also plays a regulatory role in several signal transduction pathways that are frequent targets for mutagenesis in human tumors. Much research performed on the SKI protein is based on the role it plays in the proliferation of cells in human melanoma<ref name="ca"> Marcelain K, Hayman MJ. Fall 2005. The Ski oncoprotein is upregulated by localized centrosomes and mitotic spindle during metosis. http://www.nature.com/onc/journal/v24/n27/full/1208631a.html</ref>. | ||
== References == | == References == | ||
<references/> | <references/> | ||