P53R2: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Stéphanie Kraemer, David Canner, Stéphanie Kilens, Michal Harel

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- {{STRUCTURE_3hf1|  PDB=3hf1  |  SCENE=  }}
+{{STRUCTURE_3hf1|  PDB=3hf1  | SIZE=400| SCENE=P53R2/P53r2/3 |right|CAPTION=p53R2 complex with Fe and sulfate ions, [[3hf1]] }}
-P53R2 is an oxydoreductase composed of 351 residues. It is a small subunit of the ribonucleotide reductase (RNR).
+[[Image:3hf1.png|left|200px]]
+[[p53R2]] is an oxydoreductase composed of 351 residues, that could be a new target for an anticancer therapy. It is a small subunit of the ribonucleotide reductase (RNR).
 RNR catalyses the reduction of the four nucleotides to desoxyribonucleotides. It exists three classes of RNR. Class I RNR is a tetramer composed of the two types of subunits with stoichiometry α2β2 and three subunits have been identified in mammals :
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 p53R2 is included in the RR class I which are characterized by a tyrosyl radical coupled with diiron cluster. A protein which possess tyrosyl radicals with binuclear center is known to have an oxidative or a reductive effect. So for the researchers Lijun Xue et al. <ref>PMID:16488986</ref>  it raises the question of the redox properties of p53R2. They found that p53R2 is an antioxidant which can scavenge H2O2. The mitochondrial membrane is sensible to oxidative damage. H2O2 is a reactive oxygen specie (ROS) which can act on cellular growth and survival and is involved in pathogenesis like cancer. p53R2 prevents the loss of mitochondrial membrane by scavenging H2O2. This process protects cells by maintaining their genomic integrity and prevent from cancer.
+==3D structures of ribonucleotide reductase==
-=='''References'''==
+[[Ribonucleotide reductase]]
-Publications :
+==References==
+<references/>
-Smith P. et al, 2009, 2.6 A ° X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/19728742 19728742]
-Piao C. et al,2009,Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19398949 19398949]
-Xue L. et al., 2006, Structurally dependent redox property of ribonucleotide reductase subunit p53R2.PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16488986 16488986]