Interleukin-15/Sandbox: Difference between revisions
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(General Description) | |||
Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases. | |||
==Structure & Function== | ==Structure & Function== | ||
==Structure== | ===Structure=== | ||
(Structural Description) | (Structural Description) | ||
(highlighting domains, folds and/or motifs) | (highlighting domains, folds and/or motifs) | ||
| Line 11: | Line 13: | ||
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load | Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load | ||
and display another structure. | and display another structure. | ||
{{STRUCTURE_2psm| PDB=2psm | SIZE=300| SCENE= |right| CAPTION=Mouse interleukin-15 complex with interleukin-15 receptor α chain and benzamidine, [[2psm]] }} | |||
==3D structures of interleukin== | |||
[[Interleukin]] | |||
[[Image:IL15-IL15Ra.png]] | |||
<!-- <Structure load='all.pdb' size='500' frame='true' align='right' {{Button Toggle AnimationOnPause}}<br> | |||
==Function== | ===Function=== | ||
(Structural insights into its function) | (Structural insights into its function) | ||
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example IL-2, IL-7 | example IL-2, IL-7 | ||
==Solved | ==Solved Structures== | ||
(Links to available structures) | (Links to available structures) | ||
2PSM | 2PSM | ||