Sandbox Reserved 313: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Justine Doherty

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 {{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}}
 =Introduction=
-'''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to [http://en.wikipedia.org/wiki/Ceramide ceramide] and [http://en.wikipedia.org/wiki/Phosphocholine phosphocholine].  This enzyme also has [http://en.wikipedia.org/wiki/Hemolytic hemolytic] activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>.  SMase is a member of the [http://en.wikipedia.org/wiki/DnaI DNA-I] superfamily involved inhydrolytic cleavage metabolism reactions.  This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [http://en.wikipedia.org/wiki/Signal_transduction signal transduction pathway] which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase  hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586  </ref>.
+'''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to [http://en.wikipedia.org/wiki/Ceramide ceramide] and [http://en.wikipedia.org/wiki/Phosphocholine phosphocholine].  This enzyme also has [http://en.wikipedia.org/wiki/Hemolytic hemolytic] activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>.  SMase is a member of the [http://en.wikipedia.org/wiki/DnaI DNA-I] superfamily involved in hydrolytic cleavage during metabolism reactions.  This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [http://en.wikipedia.org/wiki/Signal_transduction signal transduction pathway] which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase  hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586  </ref>.
 ==Types of SMase<ref name="gp3">PMID: 12401200 </ref>:==