Colicin E9: Difference between revisions
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The formation of a disulphide bond at D20C/E66C abolishes its channel forming ability, and its cytotoxicity (as it cannot penetrate cells) but has no effect on its DNase activity. It is still able to bind to the phospholipids, but not translocate across the membrane<ref> PMID: 15044477 </ref>. | The formation of a disulphide bond at D20C/E66C abolishes its channel forming ability, and its cytotoxicity (as it cannot penetrate cells) but has no effect on its DNase activity. It is still able to bind to the phospholipids, but not translocate across the membrane<ref> PMID: 15044477 </ref>. | ||
This uptake is highly similar to the uptake of [[Colicin E3]]. | |||
==Killing Activities== | ==Killing Activities== | ||