Sandbox6 Eric Martz: Difference between revisions
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* This model shows a <scene name='Sandbox6_Eric_Martz/2-88_charge/1'>noteworthy separation of charges</scene>, with a large region containing only negative charges. | * This model shows a <scene name='Sandbox6_Eric_Martz/2-88_charge/1'>noteworthy separation of charges</scene>, with a large region containing only negative charges. | ||
<center>{{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}</center> | <center>{{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}</center> | ||
*Analysis of evolutionary conservation for 2-88 is difficult because not enough related sequences are available in Uniprot. Thus most of the residues have "insufficient data" (yellow). Despite the paucity of information, there appears to be a <scene name='Sandbox6_Eric_Martz/2-88_conservation/1'>conserved patch</scene> that may be of interest. (To identify the conserved residues, toggle spinning off, then touch each residue with the mouse, and observe the popup "hover" report.) | *Analysis of evolutionary conservation for 2-88 is difficult because not enough related sequences are available in Uniprot. Thus most of the residues have "insufficient data" (yellow). Despite the paucity of information, there appears to be a <scene name='Sandbox6_Eric_Martz/2-88_conservation/1'>conserved patch</scene> that may be of interest<ref>ConSurf run with E value cutoff rat default 0.001, Uniref-90 database, 2 PSI-BLAST iterations, 18 sequences after filtration (35%/95%), average pairwise distance in the multiple sequence alignment 1.09, 57 yellow residues. Number of yellow residues was not reduced in a separate run with the E value raised to 0.03, Uniprot database, 3 PSI-BLAST iterations, and filtration at 25%/98%. This gave 22 sequences, APD 0.90, but 65 yellow residues.</ref> (To identify the conserved residues, toggle spinning off, then touch each residue with the mouse, and observe the popup "hover" report.) | ||
<table align="right"><tr><td>{{Template:ColorKey_ConSurf_NoGray}}</td></tr></table> | **<scene name='Sandbox6_Eric_Martz/2-88_conservation/2'>Cartoon</scene><table align="right"><tr><td>{{Template:ColorKey_ConSurf_NoGray}}</td></tr></table> | ||
** | **<scene name='Sandbox6_Eric_Martz/2-88_conservation/3'>Cartoon decorated with conserved residues</scene> | ||
**<scene name='Sandbox6_Eric_Martz/2-88_conservation/1'>Spacefilling</scene> | **<scene name='Sandbox6_Eric_Martz/2-88_conservation/1'>Spacefilling</scene> | ||
*This model can be downloaded from [[:Image:Caspase12-homology-model-2-88-on-1dgn-a.pdb|model-2-88]]. | *This model can be downloaded from [[:Image:Caspase12-homology-model-2-88-on-1dgn-a.pdb|model-2-88]]. | ||