Molecular Playground/Tamiflu: Difference between revisions
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{{Template:MP_masthead}} | {{Template:MP_masthead}} | ||
The [http://www.who.int World Health Organization] and the governments of many countries have collectively stockpiled hundreds of millions of dollars worth of the anti-influenza drug Tamiflu in order to be prepared for an influenza pandemic. | The [http://www.who.int World Health Organization] and the governments of many countries have collectively stockpiled hundreds of millions of dollars worth of the anti-influenza drug Tamiflu in order to be prepared for an influenza pandemic. | ||
It is lucky that the H1N1 "swine flu" that arose in Mexico in 2009 is treatable by (sensitive to) Tamiflu. Many strains of influenza are no longer treatable with Tamiflu. They have developed mutations that make them resistant to the drug. Notably, the H5N1 avian influenza, a likely source of a future pandemic, is largely resistant. Unfortunately, as human cases of H1N1 flu are treated with Tamiflu, it, too, will likely soon develop drug resistance. | It is lucky that the H1N1 "swine flu" that arose in Mexico in 2009 is treatable by (sensitive to) Tamiflu. Many strains of influenza are no longer treatable with Tamiflu. They have developed mutations that make them resistant to the drug. Notably, the H5N1 avian influenza, a likely source of a future pandemic, is largely resistant. Unfortunately, as human cases of H1N1 flu are treated with Tamiflu, it, too, will likely soon develop drug resistance. | ||
{{Clear}} | |||
<applet size='[450,350]' frame='true' align='right' caption='Tamiflu' | |||
scene='User:Eric_Martz/Molecular_Playground/Tamiflu/2hu4_chain_a_dot_pdb/3' /> | |||
Shown at right (<scene name='User:Eric_Martz/Molecular_Playground/Tamiflu/2hu4_chain_a_dot_pdb/3'>restore initial scene</scene>) is the drug Tamiflu (generic name oseltamivir; some parts not shown<ref>The Tamiflu structure shown on this page is that resolved by [[X-ray diffraction]] at 2.5 Å [[Resolution|resolution]] in [[2hu4]]: [[Hydrogen in macromolecular models|hydrogens]] are not shown, some double bonds are not shown, and the ethyl group that esterifies the carboxylate is missing -- see [http://www.tamiflu.com Tamiflu.Com] or [http://en.wikipedia.org/wiki/Oseltamivir oseltamivir at Wikipedia] for the complete structure.</ref>). | Shown at right (<scene name='User:Eric_Martz/Molecular_Playground/Tamiflu/2hu4_chain_a_dot_pdb/3'>restore initial scene</scene>) is the drug Tamiflu (generic name oseltamivir; some parts not shown<ref>The Tamiflu structure shown on this page is that resolved by [[X-ray diffraction]] at 2.5 Å [[Resolution|resolution]] in [[2hu4]]: [[Hydrogen in macromolecular models|hydrogens]] are not shown, some double bonds are not shown, and the ethyl group that esterifies the carboxylate is missing -- see [http://www.tamiflu.com Tamiflu.Com] or [http://en.wikipedia.org/wiki/Oseltamivir oseltamivir at Wikipedia] for the complete structure.</ref>). | ||
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{{Template:Molecular Playground animation description}} | {{Template:Molecular Playground animation description}} | ||
'''Methods.''' The ''Play Animation'' button above runs a [[Jmol]] command script, which was authored by hand, and uploaded to Proteopedia. You can examine the script at [[Image:MP tamiflu.spt]], which calls [[Image:MPSupportVersion01.spt]]. The [[Atomic coordinate file|atomic coordinate file]] ([[PDB file]]) displayed above ([[Image:2hu4_chain_a.pdb]]) contains chain A from [[2hu4]]. | '''Methods.''' The ''Play Animation'' button above runs a [[Jmol]] command script, which was [[Molecular Playground/Authoring|authored by hand]], and uploaded to Proteopedia. You can examine the script at [[Image:MP tamiflu.spt]], which calls [[Image:MPSupportVersion01.spt]] (see also [[Molecular Playground/Authoring]]). The [[Atomic coordinate file|atomic coordinate file]] ([[PDB file]]) displayed above ([[Image:2hu4_chain_a.pdb]]) contains chain A from [[2hu4]]. | ||
==Additional Resources== | |||
For additional information, see: [[Influenza]] | |||
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==Notes== | ==Notes== | ||
<references /> | <references /> | ||
[[Category: Molecular Playground]] | |||