Jasper Sandbox: Difference between revisions
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==Overview== | ==Overview== | ||
HRAS is an intercellular GTPase switch protein. It is directly involved with regulating cell growth, and is one of the first steps in the pathway. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. HRAS is downstream from most RTK's, and the pathway culminates with the activation of MAP kinase. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. The SOS protein binds to a distal and active site on HRAS. It has also been shown that | HRAS is an intercellular GTPase switch protein. It is directly involved with regulating cell growth, and is one of the first steps in the pathway. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. HRAS is downstream from most RTK's, and the pathway culminates with the activation of MAP kinase. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. The SOS protein binds to a distal and active site on HRAS. It has also been shown that prenylation of SOS is necessary for interactions with HRAS. | ||
==Mutations== | ==Mutations== | ||
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==Reference== | ==Reference== | ||
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis., Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A, EMBO J. 1990 Aug;9(8):2351-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2196171 2196171] | Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis., Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A, EMBO J. 1990 Aug;9(8):2351-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2196171 2196171] | ||
Aoki, Y.; Niihori, T.; Kawame, H.; Kurosawa, K.; Ohashi, H.; Tanaka, Y.; Filocamo, M.; Kato, K.; Suzuki, Y.; Kure, S.; Matsubara, Y. : | Aoki, Y.; Niihori, T.; Kawame, H.; Kurosawa, K.; Ohashi, H.; Tanaka, Y.; Filocamo, M.; Kato, K.; Suzuki, Y.; Kure, S.; Matsubara, Y. : | ||
Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nature Genet. 37: 1038-1040, 2005. | Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nature Genet. 37: 1038-1040, 2005. | ||
Pechlivanis M, Ringel R, Popkirova B, Kuhlmann J. Prenylation of Ras facilitates hSOS1-promoted nucleotide exchange, upon Ras binding to the regulatory site | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:36:34 2008'' | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:36:34 2008'' | ||