View source for Interleukin receptor antagonist

<StructureSection load='1ilr' size='340' side='right' caption='Human interleukin-1 receptor antagonist dimer, [[1ilr]]' scene=''>
== Function ==
'''Interleukin-1 receptor antagonist''' (IL1RA) is a member of the interleukin-1 (IL1) cytokine family.  IL1RA inhibits the activity of IL1, IL1A and IL1B.  IL1RA modulates the activity of IL1-related immune and inflammatory responses.  IL1RA binds to the IL1 receptor on the cell surface<ref>PMID:9597123</ref>.

== Relevance ==
'''IL1RA''' (or anakinra) is used as a drug in the treatment of rheumatoid arthritis<ref>PMID:19160248</ref>.  '''IL36RA''' mutations lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis<ref>PMID:21848462</ref>.
</StructureSection>

==3D structures of IL1RA==

[[2irt]], [[1ilr]], [[1ilt]] – hIL1RA – human<br />
[[1irp]] - hIL1RA – NMR<br />
[[1ira]] - hIL1RA + interleukin-1 receptor extracellular domain<br />
[[4p0j]], [[4p0k]], [[4p0l]] – hIL36RA/IL36 γ (mutant)<br />
== References ==
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