View source for Human PI3K p110alpha/p85alpha

<StructureSection load="2rd0" size="400" color="" frame="true"  spin="on" Scene=  side="right" caption='Human PI3K catalytic subunit p110 (grey) and regulatory subunit p85 (green) (PDB code [[2rd0]])' >

[[Image:2rd0.jpg|left|200px]]
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===Structure of a human p110alpha/p85alpha complex ([[2rd0]])===
(see also [[Phosphoinositide 3-Kinases]])<br />
{{ABSTRACT_18079394}}

==Disease==
Known disease associated with this structure: Breast cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Gastric cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Hepatocellular carcinoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Nonsmall cell lung cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Ovarian cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]]

==About this Structure==
2RD0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD0 OCA]. 

==Figures From The Publication==


<big>
* <scene name='2rd0/Figure_1_colors/2'>Figure 1B</scene>
* <scene name='2rd0/Figure_1_colors/6'>Figure 1C</scene> (Labeled)
* <scene name='2rd0/Figure_1_colors/12'>Fig. 1C Spacefilled</scene> (Labeled)
* <scene name='2rd0/Figure_1_colors/7'>Figure 2A</scene>
* <scene name='2rd0/Figure_1_colors/9'>Figure 2C</scene>
* <scene name='2rd0/Figure_1_colors/8'>Figure 2C</scene> (Distant portions hidden)
* <scene name='2rd0/Figure_1_colors/11'>Figure 2C</scene> (Showing distances)
* (Figure 2D <small>requires a model containing the nSH2 domain, not present in the published model 2rd0.</small>) 
* Re: Figure 3 -- <scene name='2rd0/Charges/1'>Surface Charges</scene>:
<font color='#ffa0a0'><b>iSH2 (chain B)</b></font>, 
<font color='red'><b>Negative</b></font>, 
<font color='blue'><b>Positive</b></font>.
<small><small><br>
<font color='red'><b>Asp, Glu sidechain oxygens</b></font>, 
<font color='blue'><b>Lys, Arg terminal sidechain nitrogens</b></font>.
No sidechains lack coordinates in this model.
</small></small>
* Figure 2E: <scene name='2rd0/Figure_1_colors/13'>Overview/Location</scene>,
<scene name='2rd0/Figure_1_colors/14'>As Printed</scene>
</big>


The following residues are [http://dunbrack.fccc.edu/Guoli/s2c/get_s2c_file.cgi?pdbid=2rd0&submit=Submit missing in the model] (lack coordinates):
*Chain A: 1-7, 307-324, 415-423, 506-527, 941-950. The last modeled residue is 1050.
*Chain B: 1-441, 510-520, 584-592. The last modeled residue is 600.
<br clear="both">

[[Category: Homo sapiens]]
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
[[Category: Protein complex]]
[[Category: Amzel, L M.]]
[[Category: Gabelli, S B.]]
[[Category: Huang, C.]]
[[Category: Alternative splicing]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Kinase]]
[[Category: Oncogene]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Transferase]]
[[Category: Transferase/oncoprotein complex]]
[[Category: Ubl conjugation]]
<br />
Created with the participation of [[User:Eric Martz|Eric Martz]], [[User:Eran Hodis|Eran Hodis]], [[User:Jaime Prilusky|Jaime Prilusky]].