View source for Human Follicle-Stimulating Hormone Complexed with its Receptor

{{Article under development}}
NEEDS UPDATING TO INCLUDE [[4ay9]].
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===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor===
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==Disease==
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<table width=380' align='right' cellpadding='0'><tr><td bgcolor='#eeeeee'>{{Structure
|PDB=
|SIZE=350|SCENE=Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4|CAPTION= Glycosylated FSH complex with acetylamino-deoxy-pyranose and sulfate binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor ([[1fl7]] morphing to [[1xwd]], [[resolution]] 2.92&Aring;)
|SITE= 
|LIGAND=
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=
|COORDINATES=
}}</td></tr><tr><td bgcolor='#eeeeee'><center>
{{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4'>Initial scene</scene>
</center></td></tr></table>
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]]

==About this Structure==
1XWD is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA]. 


The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/4'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[Leucine-rich repeat|leucine-rich repeats]] often are horseshoe- or arc-shaped.<br\>
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Add about cysteine-knot. <br\>
Add about seat belt.<br\>
Keep in mind this is just the leucine-rich repeat, amino-terminal portion of the receptor and that in the full receptor structure part of the chain also forms a  [[G protein-coupled receptor]] and a brief intracellular domain at the C-terminus.

==References==
<ref group="xtra">PMID:15662415</ref><references group="xtra"/>
<ref group="xtra">PMID:22802634 </ref><references group="xtra"/>

==See also==
*[[Leucine-rich repeat|Leucine-rich repeat proteins]]
* [[Hormone]]
* [[Membrane proteins]]
*[[Receptor]]
*[[Transmembrane (cell surface) receptors]]
*[[G protein-coupled receptors]]
* [[1hcn]] - human chorionic gonadotropin placental hormone
* [[1hrp]] - human chorionic gonadotropin placental hormone
* [[1hd4]] - human chorionic gonadotropin placental hormone alpha subunit
* [[3g04]] - Human thyroid-stimulating hormone receptor in complex with a thyroid-stimulating autoantibody

==3D structures of follicle-stimulating hormone==

See [[Follicle-stimulating hormone]]

==External Resources==
* [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors]
* [http://gris.ulb.ac.be/ GRIS: Glycoprotein-hormone Receptors Information System]

[[Category: Homo sapiens]]
[[Category: Fan, Q R.]]
[[Category: Hendrickson, W A.]]
[[Category: Cysteine-knot motif]]
[[Category: Hormone-receptor complex]]
[[Category: Leucine-rich repeat]]
[[Category:Topic Page]]

''Page originally seeded at [[1xwd]] by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:34:49 2009''