View source for C-X-C motif chemokine

<StructureSection load='1qg7' size='350' side='right' caption='CXCL12α dimer complex with sulfate (PDB code [[1qg7]]).' scene=''>

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== Function ==  

'''C-X-C motif chemokine''' (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal.  The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.<ref>PMID:16212895</ref><br />

•	'''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br />
•	'''CXCL3''' or '''platelet factor 3''' is involved in the development of prostate cancer<ref>PMID:29524043</ref><br />
•	'''CXCL4''' or '''platelet factor 4''' is a pro-inflammatory compound<ref>PMID:27183218</ref><br />
•	'''CXCL7''' or '''platelet factor 7''' promotes neutrophil adhesion and transmigration<ref>PMID:12193731</ref><br />
•	'''CXCL10''' or '''IP-10''' or '''interferon γ-induced protein 10''' acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3<ref>PMID:19105984</ref><br />
•	'''CXCL11''' or '''IP-9''' or '''interferon γ-induced protein 9''' acts as chemotactic for activated T cells.<br />
•	'''CXCL12''' or '''Stromal-Derived-Factor-1''' (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis<ref>PMID:24024928</ref><br />
•	'''CXCL14''' or '''BRAK''' acts as chemotactic for monocytes and inhibits angiogenesis.<br />

== Relevance ==

CXCL4 plays an important role in pancreatic inflammation and can be targeted to ameliorate tissue damage in pancreatitis.  Levels of CXCL4 are elevated in patients with systemic sclerosis<ref>PMID:24350901</ref>.  CXCL12 may be involved in the immune defense pathway during periodontal disease<ref>PMID:18454663</ref>.

== 3D Structures of C-X-C motif chemokine ==
[[C-X-C motif chemokine 3D structures]]

</StructureSection>

== References ==
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