View source for 8yh0


==A3R-Gi complex bound to NECA==
<StructureSection load='8yh0' size='340' side='right'caption='[[8yh0]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yh0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Victoria/3/1975(H3N2)) Influenza A virus (A/Victoria/3/1975(H3N2))], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YH0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yh0 OCA], [https://pdbe.org/8yh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yh0 RCSB], [https://www.ebi.ac.uk/pdbsum/8yh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yh0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/W5QED6_SHEEP W5QED6_SHEEP] Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.[RuleBase:RU201114][https://www.uniprot.org/uniprot/A0A5P9VSM6_HRSV A0A5P9VSM6_HRSV] [https://www.uniprot.org/uniprot/HEMA_I75A3 HEMA_I75A3] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ovis aries]]
[[Category: Rattus rattus]]
[[Category: Nureki O]]
[[Category: Oshima HS]]
[[Category: Shihoya W]]