View source for 8ov6


==Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB==
<StructureSection load='8ov6' size='340' side='right'caption='[[8ov6]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ov6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OV6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U79:methyl+2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate'>U79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ov6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ov6 OCA], [https://pdbe.org/8ov6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ov6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ov6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ov6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCA16_HUMAN DCA16_HUMAN] Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.<ref>PMID:16949367</ref> <ref>PMID:31209349</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ciulli A]]
[[Category: Cowan AD]]
[[Category: Nakasone MA]]
[[Category: Sundaramoorthy R]]