View source for 8k4l


==Crystal structure of NRF1 homodimer in complex with DNA==
<StructureSection load='8k4l' size='340' side='right'caption='[[8k4l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8k4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K4L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k4l OCA], [https://pdbe.org/8k4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k4l RCSB], [https://www.ebi.ac.uk/pdbsum/8k4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k4l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NRF1_HUMAN NRF1_HUMAN] Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Li WF]]
[[Category: Liu K]]
[[Category: Min JR]]