View source for 8hoy


==Cryo-EM structure of monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex without DNA at 2.76 angostram==
<StructureSection load='8hoy' size='340' side='right'caption='[[8hoy]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8hoy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HOY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hoy OCA], [https://pdbe.org/8hoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hoy RCSB], [https://www.ebi.ac.uk/pdbsum/8hoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hoy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOL_MONPV DPOL_MONPV] Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral OPG148 and OPG116 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform OPG116/D4synthesis across an abasic site.[UniProtKB:P06856]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Monkeypox virus]]
[[Category: Dong C]]
[[Category: Fan R]]
[[Category: Li D]]
[[Category: Wu Y]]
[[Category: Xu Y]]
[[Category: Yang B]]
[[Category: Yang Y]]
[[Category: Zhang Y]]
[[Category: Zhang Z]]