View source for 8fma


==Nodavirus RNA replication proto-crown, detergent-solubliized C11 multimer==
<StructureSection load='8fma' size='340' side='right'caption='[[8fma]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fma]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FMA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fma OCA], [https://pdbe.org/8fma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fma RCSB], [https://www.ebi.ac.uk/pdbsum/8fma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fma ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RDRP_FHV RDRP_FHV] RNA-dependent RNA polymerase, which replicates the viral genome composed of 2 RNA segments, RNA1 and RNA2 (Probable). Does not need an exogenous primer (PubMed:24466277). Also possesses a terminal nucleotidyl transferase (TNTase) activity (PubMed:24466277). The TNTase catalyzes the addition of nucleotide to the 3'-end of plus- and minus-stranded RNAs, probably to repair the 3'-end nucleotide loss (PubMed:24466277). Forms the open necked connection to the cytosol of the virus-induced replication vesicles (PubMed:32690711, PubMed:36560715, PubMed:36693094). Mediates viral RNA1 recruitment (PubMed:17301137).<ref>PMID:17301137</ref> <ref>PMID:24466277</ref> <ref>PMID:32690711</ref> <ref>PMID:36560715</ref> <ref>PMID:36693094</ref> <ref>PMID:24466277</ref> 

==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Flock House virus]]
[[Category: Large Structures]]
[[Category: Ahlquist P]]
[[Category: Broadberry R]]
[[Category: Grant T]]
[[Category: Horswill M]]
[[Category: Myers J]]
[[Category: Pennington J]]
[[Category: Rebolledo Viveros A]]
[[Category: Unchwaniwala N]]
[[Category: Zhan H]]
[[Category: Den Boon J]]