View source for 8esk


==Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state==
<StructureSection load='8esk' size='340' side='right'caption='[[8esk]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8esk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene>, <scene name='pdbligand=RBR:rocuronium'>RBR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esk OCA], [https://pdbe.org/8esk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esk RCSB], [https://www.ebi.ac.uk/pdbsum/8esk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACHA_TETCF ACHA_TETCF] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Tetronarce californica]]
[[Category: Goswami U]]
[[Category: Hibbs RE]]
[[Category: Rahman MM]]
[[Category: Teng J]]