View source for 8d1f


==hBest2 5mM Ca2+ (Ca2+-bound) closed state==
<StructureSection load='8d1f' size='340' side='right'caption='[[8d1f]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8d1f]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DU0:2-[2-[(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]-16-yl]oxyethyl]propane-1,3-diol'>DU0</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1f OCA], [https://pdbe.org/8d1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1f RCSB], [https://www.ebi.ac.uk/pdbsum/8d1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BEST2_HUMAN BEST2_HUMAN] Forms calcium-sensitive chloride channels. Permeable to bicarbonate.<ref>PMID:11904445</ref> <ref>PMID:12907679</ref> <ref>PMID:18400985</ref> 

==See Also==
*[[Bestrophin 3D structures|Bestrophin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hendrickson WA]]
[[Category: Kittredge A]]
[[Category: Owji AP]]
[[Category: Tingting Y]]