View source for 8cxc


==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics==
<StructureSection load='8cxc' size='340' side='right'caption='[[8cxc]], [[Resolution|resolution]] 4.31&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cxc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.31&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxc OCA], [https://pdbe.org/8cxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxc RCSB], [https://www.ebi.ac.uk/pdbsum/8cxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
== Function ==
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>   Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> 

==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bandaranayake AD]]
[[Category: Carter J]]
[[Category: Chan MK]]
[[Category: Clarke M]]
[[Category: Correnti CE]]
[[Category: Friend DJ]]
[[Category: Lin I]]
[[Category: Mehlin C]]
[[Category: Meshinchi S]]
[[Category: Olson JM]]
[[Category: Pilat K]]
[[Category: Ruff RO]]
[[Category: Rupert PB]]
[[Category: Strong RK]]