View source for 8chv


==Crystal structure of human PURA (fragment Glu57-Glu212, PUR repeat I and II) R140P mutant==
<StructureSection load='8chv' size='340' side='right'caption='[[8chv]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8chv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CHV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8chv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8chv OCA], [https://pdbe.org/8chv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8chv RCSB], [https://www.ebi.ac.uk/pdbsum/8chv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8chv ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PURA_HUMAN PURA_HUMAN] Severe neonatal hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion;PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PURA_HUMAN PURA_HUMAN] This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Janowski R]]
[[Category: Niessing D]]