View source for 8bw2


==PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative==
<StructureSection load='8bw2' size='340' side='right'caption='[[8bw2]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5s9f 5s9f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y3Y:(2R)-N-(2-methoxyethyl)-2-methyl-4-thiophen-2-ylcarbonyl-piperazine-1-carboxamide'>Y3Y</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw2 OCA], [https://pdbe.org/8bw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> 

==See Also==
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aimon A]]
[[Category: Biggin PC]]
[[Category: Bradshaw WJ]]
[[Category: Douangamath A]]
[[Category: Grosjean H]]
[[Category: Hassell-Hart S]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: Spencer J]]
[[Category: Talon R]]
[[Category: Von Delft F]]