View source for 7w6p


==Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist==
<StructureSection load='7w6p' size='340' side='right'caption='[[7w6p]], [[Resolution|resolution]] 3.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7w6p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W96:N-pyridin-4-ylisoquinolin-4-amine'>W96</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6p OCA], [https://pdbe.org/7w6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6p RCSB], [https://www.ebi.ac.uk/pdbsum/7w6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6p ProSAT]</span></td></tr>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Du Y]]
[[Category: Fink EA]]
[[Category: Shoichet BK]]
[[Category: Xu J]]