View source for 7w3y


==CryoEM structure of human Kv4.3==
<StructureSection load='7w3y' size='340' side='right'caption='[[7w3y]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7w3y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3Y FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3y OCA], [https://pdbe.org/7w3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3y RCSB], [https://www.ebi.ac.uk/pdbsum/7w3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3y ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref> 
== Function ==
[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guo JT]]
[[Category: Ma DM]]