View source for 7rlm


==Crystal Structure of Potato Leafroll Virus (PLRV) Coat Protein==
<StructureSection load='7rlm' size='340' side='right'caption='[[7rlm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rlm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Potato_leafroll_virus Potato leafroll virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RLM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rlm OCA], [https://pdbe.org/7rlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rlm RCSB], [https://www.ebi.ac.uk/pdbsum/7rlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rlm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_PLRV1 CAPSD_PLRV1] Major capsid protein that self-assembles to form an icosahedral capsid with a T=3 symmetry, about 23 nm in diameter, and consisting of 180 capsid proteins monomers (PubMed:31611039, PubMed:34813955). Most of the 180 monomers are the major capsid protein, but a small percentage contain the minor capsid protein, which has a long C-terminal extension (PubMed:31611039).<ref>PMID:31611039</ref> <ref>PMID:34813955</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Luteoviruses, poleroviruses, and enamoviruses are insect-transmitted, agricultural pathogens that infect a wide array of plants, including staple food crops. Previous cryo-electron microscopy studies of virus-like particles show that luteovirid viral capsids are built from a structural coat protein that organizes with T = 3 icosahedral symmetry. Here, we present the crystal structure of a truncated version of the coat protein monomer from potato leafroll virus at 1.80-A resolution. In the crystal lattice, monomers pack into flat sheets that preserve the two-fold and three-fold axes of icosahedral symmetry and show minimal structural deviations when compared to the full-length subunits of the assembled virus-like particle. These observations have important implications in viral assembly and maturation and suggest that the CP N-terminus and its interactions with RNA play an important role in generating capsid curvature.

Crystal structure of the potato leafroll virus coat protein and implications for viral assembly.,Adams MC, Schiltz CJ, Heck ML, Chappie JS J Struct Biol. 2021 Nov 20;214(1):107811. doi: 10.1016/j.jsb.2021.107811. PMID:34813955<ref>PMID:34813955</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7rlm" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Potato leafroll virus]]
[[Category: Adams MC]]
[[Category: Chappie JS]]
[[Category: Schiltz CJ]]