View source for 7lup


==Human TRiC/CCT complex with reovirus outer capsid protein sigma-3==
<StructureSection load='7lup' size='340' side='right'caption='[[7lup]], [[Resolution|resolution]] 6.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7lup]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LUP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lup OCA], [https://pdbe.org/7lup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lup RCSB], [https://www.ebi.ac.uk/pdbsum/7lup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lup ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN] Hereditary sensory and autonomic neuropathy with spastic paraplegia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN] Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.<ref>PMID:20080638</ref> 

==See Also==
*[[Chaperonin 3D structures|Chaperonin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mammalian orthoreovirus 3 Dearing]]
[[Category: Aebersold R]]
[[Category: Chiu W]]
[[Category: Dermody TS]]
[[Category: Frydman J]]
[[Category: Gestaut D]]
[[Category: Knowlton JJ]]
[[Category: Leitner A]]
[[Category: Ma B]]
[[Category: Prasad BVV]]
[[Category: Seven AB]]
[[Category: Shanker S]]
[[Category: Taylor G]]
[[Category: Wilson GJ]]
[[Category: Yates NA]]