View source for 7kpv


==Structure of kinase and Central lobes of yeast CKM==
<StructureSection load='7kpv' size='340' side='right'caption='[[7kpv]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7kpv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KPV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kpv OCA], [https://pdbe.org/7kpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kpv RCSB], [https://www.ebi.ac.uk/pdbsum/7kpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kpv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSN3_YEAST SSN3_YEAST] Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. Phosphorylates GCN4, promoting its ubiquitin-mediated degradation, and MSN2, promoting its nuclear exclusion. Phosphorylates STE12, thereby promoting its degradation and inhibition of filamentous growth. Phosphorylates GAL4, and this phosphorylation is required for efficient galactose-inducible transcription. Also phosphorylates BDF1 and the TAF2 subunit of the TFIID complex.<ref>PMID:10360183</ref> <ref>PMID:11226276</ref> <ref>PMID:11331604</ref> <ref>PMID:11555651</ref> <ref>PMID:12200444</ref> <ref>PMID:12520306</ref> <ref>PMID:14749387</ref> <ref>PMID:14988503</ref> <ref>PMID:15240822</ref> <ref>PMID:15601835</ref> <ref>PMID:15687503</ref> <ref>PMID:16076843</ref> <ref>PMID:16109375</ref> <ref>PMID:16630888</ref> <ref>PMID:7877695</ref> <ref>PMID:9702190</ref> <ref>PMID:9845373</ref> 

==See Also==
*[[Mediator|Mediator]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Boyer TG]]
[[Category: Chang CE]]
[[Category: Chao TC]]
[[Category: Chen SF]]
[[Category: Cholko T]]
[[Category: Garcia BA]]
[[Category: Kim HJ]]
[[Category: Li YC]]
[[Category: Murakami K]]
[[Category: Nakanishi K]]
[[Category: Tsai KL]]