View source for 7fi9


==Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D==
<StructureSection load='7fi9' size='340' side='right'caption='[[7fi9]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fi9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FI9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fi9 OCA], [https://pdbe.org/7fi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7fi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fi9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.

==See Also==
*[[NK cell receptor|NK cell receptor]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cai W]]
[[Category: Li Y]]
[[Category: Liu J]]
[[Category: Peng S]]
[[Category: Tian Y]]
[[Category: Xu T]]