View source for 7fci


==human NTCP in complex with YN69083 Fab==
<StructureSection load='7fci' size='340' side='right'caption='[[7fci]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fci]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fci OCA], [https://pdbe.org/7fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fci RCSB], [https://www.ebi.ac.uk/pdbsum/7fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fci ProSAT]</span></td></tr>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref>   (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ishimoto N]]
[[Category: Iwamoto M]]
[[Category: Iwata S]]
[[Category: Jin Z]]
[[Category: Lee W]]
[[Category: Liu K]]
[[Category: Mizutani K]]
[[Category: Muramatsu M]]
[[Category: Nishizawa T]]
[[Category: Nomura N]]
[[Category: Ohki M]]
[[Category: Oshima M]]
[[Category: Park JH]]
[[Category: Park SY]]
[[Category: Shirouzu M]]
[[Category: Son D]]
[[Category: Tame JRH]]
[[Category: Uchikubo-Kamo T]]
[[Category: Uemura T]]
[[Category: Wakita T]]
[[Category: Watashi K]]
[[Category: Yoshida H]]
[[Category: Yun JH]]