View source for 7ewh


==Crystal structure of human PHGDH in complex with Homoharringtonine==
<StructureSection load='7ewh' size='340' side='right'caption='[[7ewh]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ewh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EWH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ewh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ewh OCA], [https://pdbe.org/7ewh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ewh RCSB], [https://www.ebi.ac.uk/pdbsum/7ewh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ewh ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
== Function ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] 

==See Also==
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng YS]]
[[Category: Hsieh CH]]
[[Category: Huang HC]]
[[Category: Juan HF]]
[[Category: Lee YS]]