View source for 7esd


==Mature Donggang virus==
<SX load='7esd' size='340' side='right' viewer='molstar' caption='[[7esd]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7esd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Donggang_virus Donggang virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ESD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7esd OCA], [https://pdbe.org/7esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7esd RCSB], [https://www.ebi.ac.uk/pdbsum/7esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7esd ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Mosquito-borne flaviviruses (MBFs) adapt to a dual-host transmission circle between mosquitoes and vertebrates. Dual-host affiliated insect-specific flaviviruses (dISFs), discovered from mosquitoes, are phylogenetically similar to MBFs but do not infect vertebrates. Thus, dISF-MBF chimeras could be an ideal model to study the dual-host adaptation of MBFs. Using the pseudoinfectious reporter virus particle and reverse genetics systems, we found dISFs entered vertebrate cells as efficiently as the MBFs but failed to initiate replication. Exchange of the untranslational regions (UTRs) of Donggang virus (DONV), a dISF, with those from Zika virus (ZIKV) rescued DONV replication in vertebrate cells, and critical secondary RNA structures were further mapped. Essential UTR-binding host factors were screened for ZIKV replication in vertebrate cells, displaying different binding patterns. Therefore, our data demonstrate a post-entry cross-species transmission mechanism of MBFs, while UTR-host interaction is critical for dual-host adaptation.

Replication is the key barrier during the dual-host adaptation of mosquito-borne flaviviruses.,Zhang Y, Liang D, Yuan F, Yan Y, Wang Z, Liu P, Yu Q, Zhang X, Wang X, Zheng A Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2110491119. doi: , 10.1073/pnas.2110491119. Epub 2022 Mar 16. PMID:35294288<ref>PMID:35294288</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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[[Category: Donggang virus]]
[[Category: Large Structures]]
[[Category: Liang D]]
[[Category: Zhang Y]]