View source for 7d3m


==FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY R50==
<StructureSection load='7d3m' size='340' side='right'caption='[[7d3m]], [[Resolution|resolution]] 3.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7d3m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D3M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.94&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d3m OCA], [https://pdbe.org/7d3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d3m RCSB], [https://www.ebi.ac.uk/pdbsum/7d3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d3m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G3E3P7_FMDVO G3E3P7_FMDVO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The development of a universal vaccine against foot-and-mouth disease virus (FMDV) is hindered by cross-serotype antigenic diversity and by a lack of knowledge regarding neutralization of the virus in natural hosts. In this study, we isolated serotype O-specific neutralizing antibodies (NAbs) (F145 and B77) from recovered natural bovine hosts by using the single B cell antibody isolation technique. We also identified a serotype O/A cross-reacting NAb (R50) and determined virus-NAb complex structures by cryo-electron microscopy at near-atomic resolution. F145 and B77 were shown to engage the capsid of FMDV-O near the icosahedral threefold axis, binding to the BC/HI-loop of VP2. In contrast, R50 engages the capsids of both FMDV-O and FMDV-A between the 2- and 5-fold axes and binds to the BC/EF/GH-loop of VP1 and to the GH-loop of VP3 from two adjacent protomers, revealing a previously unknown antigenic site. The cross-serotype neutralizing epitope recognized by R50 is highly conserved among serotype O/A. These findings help to elucidate FMDV neutralization by natural hosts and provide epitope information for the development of a universal vaccine for cross-serotype protection against FMDV.

Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization.,He Y, Li K, Cao Y, Sun Z, Li P, Bao H, Wang S, Zhu G, Bai X, Sun P, Liu X, Yang C, Liu Z, Lu Z, Rao Z, Lou Z PLoS Pathog. 2021 Apr 28;17(4):e1009507. doi: 10.1371/journal.ppat.1009507. , eCollection 2021 Apr. PMID:33909694<ref>PMID:33909694</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7d3m" style="background-color:#fffaf0;"></div>

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Foot-and-mouth disease virus]]
[[Category: Large Structures]]
[[Category: He Y]]
[[Category: Lou Z]]