View source for 7b6j


==Crystal structure of MurE from E.coli in complex with minifrag succinimide==
<StructureSection load='7b6j' size='340' side='right'caption='[[7b6j]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7b6j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZB:succinimide'>SZB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6j OCA], [https://pdbe.org/7b6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6j RCSB], [https://www.ebi.ac.uk/pdbsum/7b6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref> 

==See Also==
*[[Mur ligase|Mur ligase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Fairhead M]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: Steindel M]]
[[Category: Von Delft F]]