View source for 7b5o


==Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution==
<StructureSection load='7b5o' size='340' side='right'caption='[[7b5o]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7b5o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B5O FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I74:(3R,4R)-4-[[[7-[(PHENYLMETHYL)AMINO]-3-PROPAN-2-YL-PYRAZOLO[1,5-A]PYRIMIDIN-5-YL]AMINO]METHYL]PIPERIDIN-3-OL'>I74</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5o OCA], [https://pdbe.org/7b5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5o RCSB], [https://www.ebi.ac.uk/pdbsum/7b5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5o ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref> 

==See Also==
*[[Cyclin 3D structures|Cyclin 3D structures]]
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ali S]]
[[Category: Greber BJ]]
[[Category: Nogales E]]
[[Category: Remis J]]