View source for 7b4b


==Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)==
<StructureSection load='7b4b' size='340' side='right'caption='[[7b4b]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B4B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QN8:(2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one'>QN8</scene>, <scene name='pdbligand=QNN:(2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one'>QNN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b4b OCA], [https://pdbe.org/7b4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b4b RCSB], [https://www.ebi.ac.uk/pdbsum/7b4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b4b ProSAT]</span></td></tr>
</table>

==See Also==
*[[P53 3D structures|P53 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Degtjarik O]]
[[Category: Rozenberg H]]
[[Category: Shakked Z]]