View source for 7ahl


==ALPHA-HEMOLYSIN FROM STAPHYLOCOCCUS AUREUS==
<StructureSection load='7ahl' size='340' side='right'caption='[[7ahl]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ahl]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AHL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ahl OCA], [https://pdbe.org/7ahl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ahl RCSB], [https://www.ebi.ac.uk/pdbsum/7ahl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ahl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/7ahl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=7ahl ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Hemolysin|Hemolysin]]
*[[Hemolysin 3D structures|Hemolysin 3D structures]]
*[[Pore forming toxin%2C ÃÂ±-hemolysin|Pore forming toxin%2C ÃÂ±-hemolysin]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Bayley H]]
[[Category: Cheley S]]
[[Category: Gouaux JE]]
[[Category: Hobaugh M]]
[[Category: Shustak C]]
[[Category: Song L]]