View source for 6ykm


==Structure of C. jejuni MotAB==
<StructureSection load='6ykm' size='340' side='right'caption='[[6ykm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ykm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81-176 Campylobacter jejuni subsp. jejuni 81-176]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YKM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ykm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ykm OCA], [https://pdbe.org/6ykm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ykm RCSB], [https://www.ebi.ac.uk/pdbsum/6ykm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ykm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3PAV1_CAMJJ A0A0H3PAV1_CAMJJ] 
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== Publication Abstract from PubMed ==
Many bacteria use the flagellum for locomotion and chemotaxis. Its bidirectional rotation is driven by a membrane-embedded motor, which uses energy from the transmembrane ion gradient to generate torque at the interface between stator units and rotor. The structural organization of the stator unit (MotAB), its conformational changes upon ion transport, and how these changes power rotation of the flagellum remain unknown. Here, we present ~3 A-resolution cryoelectron microscopy reconstructions of the stator unit in different functional states. We show that the stator unit consists of a dimer of MotB surrounded by a pentamer of MotA. Combining structural data with mutagenesis and functional studies, we identify key residues involved in torque generation and present a detailed mechanistic model for motor function and switching of rotational direction.

Structure and Function of Stator Units of the Bacterial Flagellar Motor.,Santiveri M, Roa-Eguiara A, Kuhne C, Wadhwa N, Hu H, Berg HC, Erhardt M, Taylor NMI Cell. 2020 Sep 7. pii: S0092-8674(20)31007-2. doi: 10.1016/j.cell.2020.08.016. PMID:32931735<ref>PMID:32931735</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6ykm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Campylobacter jejuni subsp. jejuni 81-176]]
[[Category: Large Structures]]
[[Category: Roa-Eguiara A]]
[[Category: Santiveri M]]
[[Category: Taylor NMI]]