View source for 6tnp


==Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide==
<StructureSection load='6tnp' size='340' side='right'caption='[[6tnp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tnp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO8:(2~{S})-~{N}-[2-[[(2~{S})-1-[[(2~{S},3~{R})-3-[(2~{S},3~{R},4~{R},5~{R},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-1-[[(2~{S})-1-[(2~{S})-2-aminocarbonylpyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]-1-[(2~{S})-2-azanylpropanoyl]pyrrolidine-2-carboxamide'>NO8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnp OCA], [https://pdbe.org/6tnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tnp RCSB], [https://www.ebi.ac.uk/pdbsum/6tnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnp ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.,Macias-Leon J, Bermejo IA, Asin A, Garcia-Garcia A, Companon I, Jimenez-Moreno E, Coelho H, Mangini V, Albuquerque IS, Marcelo F, Asensio JL, Bernardes GJL, Joshi HJ, Fiammengo R, Blixt O, Hurtado-Guerrero R, Corzana F Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. PMID:33211039<ref>PMID:33211039</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6tnp" style="background-color:#fffaf0;"></div>

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Corzana F]]
[[Category: Hurtado-Guerrero R]]
[[Category: Macias-Leon J]]