View source for 6t6l


==Mopeia Virus Exonuclease domain complexed soak with Alendronate==
<StructureSection load='6t6l' size='340' side='right'caption='[[6t6l]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6t6l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mopeia_mammarenavirus Mopeia mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T6L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.757&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t6l OCA], [https://pdbe.org/6t6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t6l RCSB], [https://www.ebi.ac.uk/pdbsum/6t6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t6l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCAP_MOPEI NCAP_MOPEI] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.[HAMAP-Rule:MF_04085]

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mopeia mammarenavirus]]
[[Category: Ferron F]]
[[Category: Nguyen THV]]