View source for 6rcn


==Crystal structure of REXO2-D199A-dAdA==
<StructureSection load='6rcn' size='340' side='right'caption='[[6rcn]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6rcn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rci|6rci]], [[6rcl|6rcl]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">REXO2, SFN, SMFN, CGI-114 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcn OCA], [http://pdbe.org/6rcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcn RCSB], [http://www.ebi.ac.uk/pdbsum/6rcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ORN_HUMAN ORN_HUMAN]] 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.<ref>PMID:23741365</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length and are assumed to constitute the final stage of RNA turnover. Here we demonstrate that REXO2 is a specialized dinucleotide-degrading enzyme that shows no preference between RNA and DNA dinucleotide substrates. A heart- and skeletal-muscle-specific knockout mouse displays elevated dinucleotide levels and alterations in gene expression patterns indicative of aberrant dinucleotide-primed transcription initiation. We find that dinucleotides act as potent stimulators of mitochondrial transcription initiation in vitro. Our data demonstrate that increased levels of dinucleotides can be used to initiate transcription, leading to an increase in transcription levels from both mitochondrial promoters and other, nonspecific sequence elements in mitochondrial DNA. Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria.

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.,Nicholls TJ, Spahr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM Mol Cell. 2019 Sep 27. pii: S1097-2765(19)30695-1. doi:, 10.1016/j.molcel.2019.09.010. PMID:31588022<ref>PMID:31588022</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6rcn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Gustafsson, C M]]
[[Category: Larsson, N G]]
[[Category: Nicholls, T J]]
[[Category: Spahr, H]]
[[Category: Hydrolase]]
[[Category: Mitochondria]]
[[Category: Oligoribonuclease]]
[[Category: Rexo2]]