View source for 6nd8


==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND BARIUM==
<StructureSection load='6nd8' size='340' side='right'caption='[[6nd8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nd8]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ND8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ND8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nd8 OCA], [https://pdbe.org/6nd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nd8 RCSB], [https://www.ebi.ac.uk/pdbsum/6nd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nd8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref> 

==See Also==
*[[Integrin 3D structures|Integrin 3D structures]]
*[[Rhodocetin|Rhodocetin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Calloselasma rhodostoma]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Loewen PC]]
[[Category: McDougall MD]]
[[Category: Stetefeld J]]