View source for 6lhf


==Crystal structure of chicken cCD8aa/pBF2*15:01==
<StructureSection load='6lhf' size='340' side='right'caption='[[6lhf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lhf]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LHF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhf OCA], [https://pdbe.org/6lhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lhf RCSB], [https://www.ebi.ac.uk/pdbsum/6lhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9GIP6_CHICK Q9GIP6_CHICK] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The CD8alphaalpha homodimer is crucial to both thymic T cell selection and the antigen recognition of cytotoxic T cells. The CD8-pMHC-I interaction can enhance CTL immunity via stabilizing the TCR-pMHC-I interaction and optimizing the cross-reactivity and Ag sensitivity of CD8(+) T cells at various stages of development. To date, only human and mouse CD8-pMHC-I complexes have been determined. Here, we resolved the pBF2*1501 complex and the cCD8alphaalpha/pBF2*1501 and cCD8alphaalpha/pBF2*0401 complexes in nonmammals for the first time. Remarkably, cCD8alphaalpha/pBF2*1501 and the cCD8alphaalpha/pBF2*0401 complex both exhibited two binding modes, including an "antibody-like" mode similar to that of the known mammal CD8/pMHC-I complexes and a "face-to-face" mode that has been observed only in chickens to date. Compared to the "antibody-like" mode, the "face-to-face" binding mode changes the binding orientation of the cCD8alphaalpha homodimer to pMHC-I, which might facilitate abundant gammadeltaT cells to bind diverse peptides presented by limited BF2 alleles in chicken. Moreover, the forces involving in the interaction of cCD8alphaalpha/pBF2*1501 and the cCD8alphaalpha/pBF2*0401 are different in this two binding model, which might change the strength of the CD8-pMHC-I interaction, amplifying T cell cross-reactivity in chickens. The coreceptor CD8alphaalpha of TCR has evolved two peptide-MHC-I binding patterns in chickens, which might enhance the T cell response to major or emerging pathogens, including chicken-derived pathogens that are relevant to human health, such as high-pathogenicity influenza viruses.

The Combination of CD8alphaalpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gammadeltaT Cells Response.,Liu Y, Chen R, Liang R, Sun B, Wu Y, Zhang L, Kaufman J, Xia C Front Immunol. 2020 Nov 23;11:605085. doi: 10.3389/fimmu.2020.605085. eCollection , 2020. PMID:33329601<ref>PMID:33329601</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6lhf" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[CD8 3D structures|CD8 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Liu YJ]]
[[Category: Xia C]]